What is the NOAEL for Tetrahydro-2H-pyran-2-one?
Tetrahydro-2H-pyran-2-one has 6 NOAEL studies in the database. The lowest reported value is 2.8 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Tetrahydro-2H-pyran-2-one
Also known as: 2H-Pyran-2-one, tetrahydro-, Oxan-2-one, Pentan-5-olide, valerolactone, EINECS 208-807-1 (+5 more)
CAS 542-28-9
Tetrahydro-2H-pyran-2-one (CAS 542-28-9) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Tetrahydro-2H-pyran-2-one is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Tetrahydro-2H-pyran-2-one
CAS Number
542-28-9
DTXSID
DTXSID6044438
Molecular Formula
C5H8O2
InChI Key
OZJPLYNZGCXSJM-UHFFFAOYSA-N
Monoisotopic Mass
100.052429
Synonyms
2H-Pyran-2-one, tetrahydro-Oxan-2-onePentan-5-olidevalerolactoneEINECS 208-807-1Penta-1,5-lactonePentanoic acid, 5-hydroxy-, delta-lactoneValeric acid, delta-hydroxy-, delta-lactonedelta-ValeryllactoneUNII-14V1X9149L
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Flavouring and nutrientNo specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =2.8 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =4.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 14V1X9149L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 14V1X9149L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 14V1X9149L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 14V1X9149L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | δ-valerolactone | 208-807-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL452383
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Tetrahydro-2H-pyran-2-one?
Tetrahydro-2H-pyran-2-one appears on 1 regulatory/inventory list including Europe. Source: EPA CPDat.
Is Tetrahydro-2H-pyran-2-one used in cosmetics?
Yes, Tetrahydro-2H-pyran-2-one is also indexed as a cosmetic ingredient under the name Delta-Valerolactone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Tetrahydro-2H-pyran-2-one come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Tetrahydro-2H-pyran-2-one have different safety status in cosmetics vs industrial chemicals?
Tetrahydro-2H-pyran-2-one is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Is Tetrahydro-2H-pyran-2-one used outside industrial chemicals?
Tetrahydro-2H-pyran-2-one also appears in cosmetics, pharmaceutical, cannabis databases.