Is Delta-Valerolactone safe in cosmetics?
Delta-Valerolactone has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Delta-Valerolactone
Also known as: 2H-Pyran-2-one, tetrahydro-, Oxan-2-one, Pentan-5-olide, valerolactone, EINECS 208-807-1 (+5 more)
INCI: DELTA-VALEROLACTONE
Delta-Valerolactone (CAS 542-28-9) is a cosmetic cosmetic ingredient functioning as Solvent and chemical intermediate. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 542-28-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Delta-Valerolactone is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Solvent and chemical intermediate
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
oxan-2-one
InChIKey
OZJPLYNZGCXSJM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR restriction for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Delta-Valerolactone.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
No specific technical function
Expert Verdict
Expert safety assessment and concern-level summary for Delta-Valerolactone.
Known Synonyms
2H-Pyran-2-one, tetrahydro-
Oxan-2-one
Pentan-5-olide
valerolactone
EINECS 208-807-1
Penta-1,5-lactone
Pentanoic acid, 5-hydroxy-, delta-lactone
Valeric acid, delta-hydroxy-, delta-lactone
delta-Valeryllactone
UNII-14V1X9149L
Chemical Function
Flavouring and nutrient
No specific technical function
Regulatory Lists
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL452383
Frequently Asked Questions
Is Delta-Valerolactone allowed in the EU?
Delta-Valerolactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Delta-Valerolactone do in cosmetics?
Delta-Valerolactone functions as: Solvent and chemical intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 542-28-9.
Is Delta-Valerolactone used outside cosmetics?
Delta-Valerolactone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Delta-Valerolactone have different safety status in cosmetics vs industrial chemicals?
Delta-Valerolactone is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Delta-Valerolactone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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