What is the NOAEL for Ammonium thioglycolate?
Ammonium thioglycolate has 8 NOAEL studies in the database. The lowest reported value is 0.937 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ammonium thioglycolate
Also known as: Acetic acid, mercapto-, monoammonium salt (1:1), Ammonium mercaptoacetate, Thioglycolic acid ammonium salt, Ammonium thioglycollate, EINECS 226-540-9 (+5 more)
CAS 5421-46-5
Ammonium thioglycolate (CAS 5421-46-5) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Ammonium thioglycolate is classified GHS Danger (H290, H301, H317, H412) in the chemicals database but is restricted in EU cosmetics at max 8%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
8
SOURCE
Chemical inventory jurisdictions
Regulatory lists
0
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Ammonium thioglycolate
CAS Number
5421-46-5
Molecular Formula
C2H4O2S.H3N
InChI Key
ZZTCCAPMZLDHFM-UHFFFAOYSA-N
Monoisotopic Mass
109.01975
Synonyms
Acetic acid, mercapto-, monoammonium salt (1:1)Ammonium mercaptoacetateThioglycolic acid ammonium saltAmmonium thioglycollateEINECS 226-540-9NSC 6954Thiofaco A-50Thioglycollic acid, ammonium saltUNII-6P9E788VZZAcetic acid, 2-mercapto-, ammonium salt (1:1)
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Reducing agentDepilatoryHair waving or straightening
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.937 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 6P9E788VZZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >25 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| >35 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| >50 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| <142 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| <200 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =3500 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ammonium mercaptoacetate | 226-540-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
restricted
Max
8%
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL3187776
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
Is Ammonium thioglycolate used in cosmetics?
Yes, Ammonium thioglycolate is also indexed as a cosmetic ingredient under the name Ammonium Thioglycolate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ammonium thioglycolate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Ammonium thioglycolate have different safety status in cosmetics vs industrial chemicals?
Ammonium thioglycolate is classified GHS Danger (H290, H301, H317, H412) in the chemicals database but is restricted in EU cosmetics at max 8%.
Is Ammonium thioglycolate used outside industrial chemicals?
Ammonium thioglycolate also appears in cosmetics, pharmaceutical databases.