Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Ammonium Thioglycolate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=172 mg/kg bw/day | dermal | - | dermal | REACH |
| NOAEL | 19 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | >=344 mg/kg bw/day | dermal | - | dermal | REACH |
| NOAEL | 0.5 other | dermal | code:3484 | dermal | REACH |
Expert Verdict
Strong odor from H2S release; highly alkaline formulations cause irritation. Mandatory warnings required on label including 'Contains thioglycolate,' 'Keep away from children,' and eye contact warnings. Not to be used on eyelashes.
Frequently Asked Questions
Is Ammonium Thioglycolate safe in cosmetics?
Strong odor from H2S release; highly alkaline formulations cause irritation. Mandatory warnings required on label including 'Contains thioglycolate,' 'Keep away from children,' and eye contact warnings. Not to be used on eyelashes. The EU classifies Ammonium Thioglycolate as "restricted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.
Is Ammonium Thioglycolate allowed in the EU?
Ammonium Thioglycolate EU regulatory status: restricted. Maximum allowed concentration: 8%. This is based on EU Regulation 1223/2009 and its amendments.
What does Ammonium Thioglycolate do in cosmetics?
Ammonium Thioglycolate functions as: Reducing agent for permanent waving, hair straightening, and depilation. It is classified as a cosmetic ingredient in our database. CAS number: 5421-46-5.
What is the Margin of Safety for Ammonium Thioglycolate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ammonium Thioglycolate?
The NOAEL (No Observed Adverse Effect Level) for Ammonium Thioglycolate is >=172 mg/kg bw/day based on a dermal study via dermal route in rat. A total of 4 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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