NOAEL Data Cosmetic Ingredient

Phenol, 4-[(2-nitrophenyl)amino]-

Also known as: EINECS 259-132-4, UNII-Z92U49184U

CAS 54381-08-7

Phenol, 4-[(2-nitrophenyl)amino]- (CAS 54381-08-7) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for HC Orange No. 1 →

SOURCE NOAEL studies
NOAEL studies
52
SOURCE Chemical inventory jurisdictions
Regulatory lists
1
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 8 fields
Name
Phenol, 4-[(2-nitrophenyl)amino]-
CAS Number
54381-08-7
DTXSID
DTXSID0068949
Molecular Formula
C12H10N2O3
InChI Key
HSDSBIUUVWRHTM-UHFFFAOYSA-N
Monoisotopic Mass
230.069142
Synonyms
EINECS 259-132-4UNII-Z92U49184U

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 52 studies
ValueUnitEndpointRouteSpeciesSource
Z92U49184UUNIIFDA UNII substance identifier--openFDA substances
Z92U49184UUNIIFDA UNII substance identifier--openFDA substances
Z92U49184UUNIIFDA UNII substance identifier--openFDA substances
Z92U49184UUNIIFDA UNII substance identifier--openFDA substances
2.5mg/kg bw/dayLOAELoralratCOSMOS DB
=0.024mg/kg bwNOAELoralratSCCS Opinion
=0.024mg/kg bwNOAELoralratSCCS Opinion
=0.024mg/kg bwNOAELoralratSCCS Opinion
=0.024mg/kg bwNOAELoralratSCCS Opinion
=0.15%NOAELdermalratSCCS Opinion
=0.15%NOAELdermalratSCCS Opinion
=0.15%NOAELdermalratSCCS Opinion
=0.15%NOAELdermalratSCCS Opinion
=25mg/kg bw/dNOAEL--SCCS Opinion
=25mg/kg bwNOAELoralratSCCS Opinion
=25mg/kg bw/dNOAEL--SCCS Opinion
=25mg/kg bwNOAELoralratSCCS Opinion
=25mg/kg bw/dNOAEL--SCCS Opinion
=25mg/kg bwNOAELoralratSCCS Opinion
=25mg/kg bw/dNOAEL--SCCS Opinion
=25mg/kg bwNOAELoralratSCCS Opinion
=75mg/kg/dayNOAELoral-SCCS Opinion
=75mg/kg bw/dayNOAEL-guinea pigSCCS Opinion
=75mg/kg/dayNOAELoral-SCCS Opinion
=75mg/kg bw/dayNOAEL-guinea pigSCCS Opinion
=75mg/kg/dayNOAELoral-SCCS Opinion
=75mg/kg bw/dayNOAEL-guinea pigSCCS Opinion
=75mg/kg/dayNOAELoral-SCCS Opinion
=75mg/kg bw/dayNOAEL-guinea pigSCCS Opinion
=250mg/kg/dayNOAELoral-SCCS Opinion
=250mg/kg/dayNOAELoral-SCCS Opinion
=250mg/kg/dayNOAELoral-SCCS Opinion
=250mg/kg/dayNOAELoral-SCCS Opinion
=300mg/kg/dayNOAELoralratSCCS Opinion
=300mg/kg/dayNOAELoralratSCCS Opinion
=300mg/kg/dayNOAELoralratSCCS Opinion
=300mg/kg/dayNOAELoralratSCCS Opinion
=750mg/kg/dayNOAELoralratSCCS Opinion
=750mg/kg/dayNOAELoralratSCCS Opinion
=750mg/kg/dayNOAELoralratSCCS Opinion
=750mg/kg/dayNOAELoralratSCCS Opinion
25mg/kg bw/dcarcinogenicity--Regulatory source
=0.024mg/kg bwdermal absorptionoralratRegulatory source
=25mg/kg bwdermal absorptionoralratRegulatory source
=25mg/kg bwdermal absorptionoralratRegulatory source
0.15%developmental toxicitydermalratRegulatory source
75mg/kg/daydevelopmental toxicityoral-Regulatory source
250mg/kg/daydevelopmental toxicityoral-Regulatory source
300mg/kg/dayrepeated dose toxicityoralratRegulatory source
750mg/kg/dayrepeated dose toxicityoralratRegulatory source

Showing 50 of 52 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
1.0%
Category
Colorant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL1339868
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for Phenol, 4-[(2-nitrophenyl)amino]-?

Phenol, 4-[(2-nitrophenyl)amino]- has 52 NOAEL studies in the database. The lowest reported value is Z92U49184U UNII. Source: openFDA substances.

What regulatory lists include Phenol, 4-[(2-nitrophenyl)amino]-?

Phenol, 4-[(2-nitrophenyl)amino]- appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.

Is Phenol, 4-[(2-nitrophenyl)amino]- used in cosmetics?

Yes, Phenol, 4-[(2-nitrophenyl)amino]- is also indexed as a cosmetic ingredient under the name HC Orange No. 1. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Phenol, 4-[(2-nitrophenyl)amino]- come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Phenol, 4-[(2-nitrophenyl)amino]- have different safety status in cosmetics vs industrial chemicals?

Phenol, 4-[(2-nitrophenyl)amino]- is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H312, H315, H319, H332, H335, H400, H411).

Is Phenol, 4-[(2-nitrophenyl)amino]- used outside industrial chemicals?

Phenol, 4-[(2-nitrophenyl)amino]- also appears in cosmetics, pharmaceutical databases.