Also known as: EINECS 259-132-4, UNII-Z92U49184U
INCI: HC ORANGE NO. 1
HC Orange No. 1 (CAS 54381-08-7) is a cosmetic cosmetic ingredient functioning as Hair dyeing — semi-permanent direct dye (orange). Reported NOAEL =0.024 mg/kg bw in rat (SCCS Opinion); EU Regulation 1223/2009 status: prohibited, max 1.0%; 1 safety opinion reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 54381-08-7 →
HC Orange No. 1 is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H312, H315, H319, H332, H335, H400, H411).
Source: Cosmetics: ingredients.eu status/eu max; Chemicals: ghs classifications.signal word/hazard statement code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Orange No. 1.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for HC Orange No. 1. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.024 mg/kg bw | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.024 mg/kg bw | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.024 mg/kg bw | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.024 mg/kg bw | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =25 mg/kg bw/d | - | - | carcinogenicity | SCCS Opinion |
| NOAEL | =25 mg/kg bw | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =25 mg/kg bw/d | - | - | carcinogenicity | SCCS Opinion |
| NOAEL | =25 mg/kg bw | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =25 mg/kg bw/d | - | - | carcinogenicity | SCCS Opinion |
| NOAEL | =25 mg/kg bw | oral | rat | dermal absorption | SCCS Opinion |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
d, the Expert Panel was reques- ted to consider a conclusion that this ingredient is safe for use in hair dyes at concentrations of at least 1% (Clairol 1996). In support of this position, the comment analyzed the possible human exposure levels that took into consideration the concentrati
Contact sensitization data for HC Orange No. 1 based on clinical patch test studies and IFRA standards.
Source: SCCS; IVDK
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 1 | Non-oxidative hair dye |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 1.03% | - | - | SCCP/1164/08 |
2 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for HC Orange No. 1.
Public NOAEL study rows linked to HC Orange No. 1 by CAS number or substance name.
Units vary across source rows: mg/kg bw, mg/kg bw/d, mg/kg/day
| Absorption % | Method | Vehicle |
|---|---|---|
| 1.03% | SCCS opinion extraction | - |
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
HC Orange No. 1 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
HC Orange No. 1 EU regulatory status: prohibited. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.
HC Orange No. 1 functions as: Hair dyeing — semi-permanent direct dye (orange). It is classified as a cosmetic ingredient in our database. CAS number: 54381-08-7.
The NOAEL (No Observed Adverse Effect Level) for HC Orange No. 1 is =0.024 mg/kg bw based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS Opinion.
HC Orange No. 1 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
HC Orange No. 1 is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H312, H315, H319, H332, H335, H400, H411).
Check HC Orange No. 1 compliance across multiple jurisdictions:
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for HC Orange No. 1 in your formulation.