HC Orange No. 1
INCI: HC ORANGE NO. 1
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for HC Orange No. 1. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 2.5 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
d, the Expert Panel was reques- ted to consider a conclusion that this ingredient is safe for use in hair dyes at concentrations of at least 1% (Clairol 1996). In support of this position, the comment analyzed the possible human exposure levels that took into consideration the concentrati
Sensitization Profile
Contact sensitization data for HC Orange No. 1 based on clinical patch test studies and IFRA standards.
Source: SCCS; IVDK
Expert Verdict
GHS H312 (harmful in contact with skin), H315 (skin irritation); acute oral exposure produced little toxicity; sub-chronic feeding at 0.5% caused increased liver/kidney weights; no reproductive/developmental toxicity at ≤1.25%
Regulatory Flags
Frequently Asked Questions
Is HC Orange No. 1 safe in cosmetics?
GHS H312 (harmful in contact with skin), H315 (skin irritation); acute oral exposure produced little toxicity; sub-chronic feeding at 0.5% caused increased liver/kidney weights; no reproductive/developmental toxicity at ≤1.25% The EU classifies HC Orange No. 1 as "prohibited". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is HC Orange No. 1 allowed in the EU?
HC Orange No. 1 EU regulatory status: prohibited. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Orange No. 1 do in cosmetics?
HC Orange No. 1 functions as: Hair dyeing — semi-permanent direct dye (orange). It is classified as a cosmetic ingredient in our database. CAS number: 54381-08-7.
What is the Margin of Safety for HC Orange No. 1?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for HC Orange No. 1?
The NOAEL (No Observed Adverse Effect Level) for HC Orange No. 1 is 2.5 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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