Also known as: 2,2'-[(4-Aminophenyl)imino]bisethanol sulfate, Ethanol, 2,2'-[(4-aminophenyl)imino]bis-, sulfate (1:1) (salt), 2,2'-((4-Aminophenyl)imino)bis(ethanol) sulfate, N,N-Bis(beta-hydroxyethyl)-p-phenylenediamine sulfate, EINECS 259-134-5 (+2 more)
CAS 54381-16-7
(p-Ammoniophenyl)bis(2-hydroxyethyl)ammonium sulphate (CAS 54381-16-7) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
View cosmetic safety profile for N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE →
(p-Ammoniophenyl)bis(2-hydroxyethyl)ammonium sulphate is classified GHS Danger (H301, H311, H315, H317, H319, H331, H400, H410) in the chemicals database but is restricted in EU cosmetics at max III/198.
CAS, identifiers, formula, and alternate names for the matched substance record.
Industrial and product-use categories associated with this substance.
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 5 | mg/kg bw/day | - | - | - | Regulatory source |
| =0.176 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 3X5A8DP6HC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 20 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| =0.003 | mg/kg | NOAEL | oral | rat | SCCS Opinion |
| 5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =5 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =5 | mg/kg bw/day | NOAEL | - | - | SCCS Opinion |
| =5 | mg/kg/day | NOAEL | oral | human | SCCS Opinion |
| =5 | mg/kg | NOAEL | oral | rat | SCCS Opinion |
| =20 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =20 | mg/kg bw/day | NOAEL | - | - | SCCS Opinion |
| =31 | mg/kg bw | NOAEL | oral | - | SCCS Opinion |
| =40 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =48 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| >=50 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =50 | mg/kg/day | NOAEL | oral | human | SCCS Opinion |
| >=121 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| >=146 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 20 | mg/kg bw/day | carcinogenicity | - | - | Regulatory source |
| =0.003 | mg/kg | dermal absorption | oral | rat | Regulatory source |
| =5 | mg/kg | dermal absorption | oral | rat | Regulatory source |
| 5 | mg/kg/day | developmental toxicity | oral | human | Regulatory source |
| 31 | mg/kg bw | developmental toxicity | oral | - | Regulatory source |
| 50 | mg/kg/day | developmental toxicity | oral | human | Regulatory source |
Showing 25 of 25 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (p-ammoniophenyl)bis(2-hydroxyethyl)ammonium sulphate | 259-134-5 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
EU Scientific Committee opinions tied to the matched substance.
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/0949/05 | 20 June 2006 | safe | 2.0% | sensitisation not excluded |
| SCCP/0983/06 | 2006-06-20 | Based on the information provided, the SCCP is of the opinion that the use of N,N-bis(2-hydroxyethyl)-p-phenylenediamine sulfate itself as an oxidative hair dye substance at a maximum concentration of 2.5% in the finished cosmetic product (after mixing with hydrogen peroxide) does not pose a risk to the health of the consumer, apart from its sensitising potential. | 2.5% (oxidative hair dye, after mixing with hydrogen peroxide) | Apart from sensitising potential; tertiary amine prone to nitrosation, should not be used with nitrosating substances, nitrosamine content < 50 ppb; genotoxicity/mutagenicity studies in finished formulations required. |
Same-CAS cosmetic ingredient record for cross-vertical context.
(p-Ammoniophenyl)bis(2-hydroxyethyl)ammonium sulphate has 25 NOAEL studies in the database. The lowest reported value is 0.176 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
Yes, (p-Ammoniophenyl)bis(2-hydroxyethyl)ammonium sulphate is also indexed as a cosmetic ingredient under the name N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
(p-Ammoniophenyl)bis(2-hydroxyethyl)ammonium sulphate is classified GHS Danger (H301, H311, H315, H317, H319, H331, H400, H410) in the chemicals database but is restricted in EU cosmetics at max III/198.
(p-Ammoniophenyl)bis(2-hydroxyethyl)ammonium sulphate also appears in cosmetics databases.