What is the NOAEL for 2-Ethylhexyl benzoate?
2-Ethylhexyl benzoate has 12 NOAEL studies in the database. The lowest reported value is 212 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Ethylhexyl benzoate
Also known as: Benzoic acid, 2-ethylhexyl ester, EINECS 226-641-8, 2-Ethyl-1-hexanol benzoate, Ethylhexyl benzoate, NSC 19155 (+1 more)
CAS 5444-75-7
2-Ethylhexyl benzoate (CAS 5444-75-7) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
2-Ethylhexyl benzoate is classified GHS Danger (H360, H360F, H413) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
12 fields
Name
2-Ethylhexyl benzoate
CAS Number
5444-75-7
DTXSID
DTXSID4041654
Molecular Formula
C15H22O2
InChI Key
UADWUILHKRXHMM-UHFFFAOYSA-N
Monoisotopic Mass
234.16198
Synonyms
Benzoic acid, 2-ethylhexyl esterEINECS 226-641-82-Ethyl-1-hexanol benzoateEthylhexyl benzoateNSC 19155UNII-R63ZWW1A13
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
11 records
SolventSoftener and conditionerSurfactant (surface active agent)Film formerWetting agent (non-aqueous)Flavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =212 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| R63ZWW1A13 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R63ZWW1A13 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R63ZWW1A13 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R63ZWW1A13 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2500 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1000 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =300 | ppm | NOAEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =1000 | ppm | NOAEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =100 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-ethylhexyl benzoate | 226-641-8 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CHEMBL3184685
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include 2-Ethylhexyl benzoate?
2-Ethylhexyl benzoate appears on 2 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Canada; pharmaceutical. Source: EPA CPDat.
Is 2-Ethylhexyl benzoate used in cosmetics?
Yes, 2-Ethylhexyl benzoate is also indexed as a cosmetic ingredient under the name Ethylhexyl Benzoate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Ethylhexyl benzoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Ethylhexyl benzoate have different safety status in cosmetics vs industrial chemicals?
2-Ethylhexyl benzoate is classified GHS Danger (H360, H360F, H413) in the chemicals database but is allowed in EU cosmetics.
Is 2-Ethylhexyl benzoate used outside industrial chemicals?
2-Ethylhexyl benzoate also appears in cosmetics, pharmaceutical, food safety databases.