Excellent Cosmetic Ingredient NOAEL Data

Ethylhexyl Benzoate

INCI: ETHYLHEXYL BENZOATE

CAS Number
5444-75-7
Function
Emollient, skin conditioning agent
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” CIR Expert Panel concluded safe as used in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Ethylhexyl Benzoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 300 mg/kg bw/day oral rat oral REACH

Expert Verdict

Long-chain alkyl benzoates permitted under general EU cosmetics provisions. CIR concluded safe with no concentration restrictions reported. Read-across from methyl/ethyl benzoate supports low sensitization risk.

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Concern Level: Low

Regulatory Flags

potential-allergen fda_food_additive

Frequently Asked Questions

Is Ethylhexyl Benzoate safe in cosmetics?

Long-chain alkyl benzoates permitted under general EU cosmetics provisions. CIR concluded safe with no concentration restrictions reported. Read-across from methyl/ethyl benzoate supports low sensitization risk. The EU classifies Ethylhexyl Benzoate as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.

Is Ethylhexyl Benzoate allowed in the EU?

Ethylhexyl Benzoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethylhexyl Benzoate do in cosmetics?

Ethylhexyl Benzoate functions as: Emollient, skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 5444-75-7.

What is the Margin of Safety for Ethylhexyl Benzoate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ethylhexyl Benzoate?

The NOAEL (No Observed Adverse Effect Level) for Ethylhexyl Benzoate is 300 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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