NOAEL Data REACH Registered Cosmetic Ingredient

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, zinc salt (2:3)

CAS 546-46-3

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, zinc salt (2:3) (CAS 546-46-3) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Zinc Citrate →

SOURCE noael studies public
NOAEL studies
4
SOURCE chemical inventory jurisdictions
Regulatory lists
4
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 6 fields
Name
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, zinc salt (2:3)
CAS Number
546-46-3
DTXSID
DTXSID90889427
Molecular Formula
2C6H8O7.3Zn
InChI Key
WGIWBXUNRXCYRA-UHFFFAOYSA-H
Monoisotopic Mass
575.841431

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 15 records
PharmaceuticalBiocide

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records
ListKeywordSource
Canada; Personal care; Substances in PCP - Canada (4/2014)Government of CanadaCPCat
Europe; supplementsEUCPCat
Europe; food_additive; supplementsEUCPCat
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 4 of 4 studies
ValueUnitEndpointRouteSpeciesSource
=1.25mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
K72I3DEX9BUNIIFDA UNII substance identifier--openFDA substances
K72I3DEX9BUNIIFDA UNII substance identifier--openFDA substances
K72I3DEX9BUNIIFDA UNII substance identifier--openFDA substances

Showing 4 of 4 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredTrizinc dicitrate208-901-2ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
1%
Category
Skin Conditioning
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL
ChEMBL Phase
Not listed
Adverse Events
90
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, zinc salt (2:3)?

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, zinc salt (2:3) has 4 NOAEL studies in the database. The lowest reported value is 1.25 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, zinc salt (2:3)?

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, zinc salt (2:3) appears on 4 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; supplements, Europe; food_additive; supplements, and 1 more. Source: EPA CPDat.

Is 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, zinc salt (2:3) used in cosmetics?

Yes, 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, zinc salt (2:3) is also indexed as a cosmetic ingredient under the name Zinc Citrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, zinc salt (2:3) come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, zinc salt (2:3) used outside industrial chemicals?

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, zinc salt (2:3) also appears in cosmetics, pharmaceutical databases.