What is the NOAEL for Magnesium carbonate (1:1)?
Magnesium carbonate (1:1) has 20 NOAEL studies in the database. The lowest reported value is 290 mg/kg body weight/d. Source: Regulatory source.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Magnesium carbonate (1:1)
Also known as: Carbonic acid, magnesium salt (1:1), Magnesium carbonate, Apolda, C.I. 77713, CSC Book Saver (+15 more)
CAS 546-93-0
Magnesium carbonate (1:1) (CAS 546-93-0) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
NOAEL studies
NOAEL studies
20
SOURCE
Chemical inventory jurisdictions
Regulatory lists
12
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
25 fields
Name
Magnesium carbonate (1:1)
CAS Number
546-93-0
Molecular Formula
CH2O3.Mg
InChI Key
ZLNQQNXFFQJAID-UHFFFAOYSA-L
Monoisotopic Mass
85.985436
Synonyms
Carbonic acid, magnesium salt (1:1)Magnesium carbonateApoldaC.I. 77713CSC Book SaverCSC Book Saver SprayCarbonate magnesiumDCI Light Magnesium CarbonateDestabFrimiz MZ 1GP 20 (carbonate)Gold Star (carbonate)
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| GHS Hazard Statements | No hazard classification according to GHS criteria |
| Long-term Effects | Lungs may be affected by repeated or prolongated exposure to dust particles. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
55 records
AbsorbentDyeOpaciferFillerBinderpH regulating agentStabilizing agentProcessing aids not otherwise specifiedFlame retardantViscosity modifierFlow promoterHeat stabilizerSurface modifierThickening agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
12 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| Europe; Personal care | European Commission | CosIng |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 20 of 20 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 290 | mg/kg body weight/d | - | - | - | Regulatory source |
| 0IHC698356 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1.25 | % | NOAEL | oral | rat | CIR Safety Assessment |
| =290 | mg/kg body weight/d | NOAEL | - | - | CIR Safety Assessment |
| >331 | mg/kg body weight/d | NOAEL | oral | rat | CIR Safety Assessment |
| =414 | mg/kg body weight/d | NOAEL | oral | rat | CIR Safety Assessment |
| <684 | mg/kg body weight/d | NOAEL | inhalation | rat | CIR Safety Assessment |
| >800 | mg/kg body weight/d | NOAEL | oral | rat | CIR Safety Assessment |
| =1000 | mg/kg body weight/d | NOAEL | oral | rat | CIR Safety Assessment |
| =1963 | mg/kg body weight | NOAEL | oral | mouse | CIR Safety Assessment |
| =4128 | mg/kg body weight/d | NOAEL | oral | rat | CIR Safety Assessment |
| 1.25 | % | developmental toxicity | oral | rat | Regulatory source |
| 414 | mg/kg body weight/d | developmental toxicity | oral | rat | Regulatory source |
| 1000 | mg/kg body weight/d | developmental toxicity | oral | rat | Regulatory source |
| 1963 | mg/kg body weight | developmental toxicity | oral | mouse | Regulatory source |
| <684 | mg/kg body weight/d | inhalation toxicity | inhalation | rat | Regulatory source |
| >331 | mg/kg body weight/d | oral toxicity | oral | rat | Regulatory source |
| >800 | mg/kg body weight/d | oral toxicity | oral | rat | Regulatory source |
| 4128 | mg/kg body weight/d | repeated dose toxicity | oral | rat | Regulatory source |
Showing 20 of 20 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Magnesium carbonate | 208-915-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
mineral
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
MAGNESIUM CARBONATE
ChEMBL Phase
4
Adverse Events
58
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
E504 — ADI: NOT LIMITED mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Magnesium carbonate (1:1)?
Magnesium carbonate (1:1) appears on 10 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, drinking_water; Europe; manufacturing; plastic_additive, and 7 more. Source: EPA CPDat.
Is Magnesium carbonate (1:1) used in cosmetics?
Yes, Magnesium carbonate (1:1) is also indexed as a cosmetic ingredient under the name Magnesium Carbonate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Magnesium carbonate (1:1) come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Magnesium carbonate (1:1) used outside industrial chemicals?
Magnesium carbonate (1:1) also appears in cosmetics, pharmaceutical, food safety, cannabis databases.