Also known as: Hexamethyl-p-rosaniline chloride, Methanaminium, N-[4-[bis[4-(dimethylamino)phenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, chloride, Crystal violet, C.I. 42555, Methanaminium, N-[4-[bis[4-(dimethylamino)phenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, chloride (1:1) (+15 more)
CAS 548-62-9
Gentian Violet (CAS 548-62-9) is a chemical substance with GHS signal word Danger; key hazard signal: H351; H302; H318; H400; H410. Key regulatory status: SVHC Candidate List, California Proposition 65, REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ECHA SVHC, CA Prop 65.
Gentian Violet is prohibited in EU cosmetics but has active industrial GHS classifications (H351, H302, H318, H400, H410, H350).
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 2021 | 129 |
Candidate List status and reason under the ECHA REACH SVHC program.
| Substance | Reason | Included |
|---|---|---|
| [4-[4,4'-bis(dimethylamino) benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride (C.I. Basic Violet 3) | Carcinogenic (Article 57a) | 18-Jun-2012 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Carc. 2; Acute Tox. 4 *; Eye Dam. 1; Aquatic Acute 1; Aquatic Chronic 1 | H351; H302; H318; H400; H410 | GHS08; GHS07; GHS05; GHS09 | Danger |
| Carc. 1B; Acute Tox. 4 *; Eye Dam. 1; Aquatic Acute 1; Aquatic Chronic 1 | H350; H302; H318; H400; H410 | GHS08; GHS07; GHS05; GHS09 | Danger |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2.02490453729919 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 1.90842079571717 | uM | ACC | - | - | NTP_ICE_endocrine |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 8.322 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =1.48 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| J4Z741D6O5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| J4Z741D6O5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| J4Z741D6O5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| J4Z741D6O5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.01384 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| =420 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.663 | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 17 of 17 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | [4-[4,4'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride | 208-953-6 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Gentian Violet (CAS 548-62-9) is classified under EU CLP Annex VI as Carc. 2; Acute Tox. 4 *; Eye Dam. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H351; H302; H318; H400; H410. Source: EU CLP Annex VI (ECHA).
Gentian Violet has 17 NOAEL studies in the database. The lowest reported value is 1.90842079571717 uM. Source: NTP_ICE_endocrine.
Gentian Violet appears on 5 regulatory/inventory lists including banned; Europe; Personal care, active_ingredient; Europe; Pesticides, OEHHA Proposition 65 (3/2019), and 2 more. Source: EPA CPDat.
Gentian Violet is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2021). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, Gentian Violet is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Yes, Gentian Violet is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Carcinogenic (Article 57a). Source: ECHA SVHC Candidate List.
Yes, Gentian Violet is also indexed as a cosmetic ingredient under the name Basic Violet 3. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ECHA SVHC Candidate List, California Proposition 65, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Gentian Violet is prohibited in EU cosmetics but has active industrial GHS classifications (H351, H302, H318, H400, H410, H350).
Gentian Violet also appears in cosmetics, pharmaceutical databases.