NOAEL Data REACH Registered Cosmetic Ingredient

2-Methyl-5-hydroxyethylaminophenol

Also known as: EINECS 259-583-7, 2-Hydroxy-4-(beta-hydroxyethyl)aminotoluene, 6-Methyl-3-beta-hydroxyethylaminophenol, 1-Methyl-2-hydroxy-4-(beta-hydroxyethyl)aminobenzene, UNII-T872B9E83J (+1 more)

CAS 55302-96-0

2-Methyl-5-hydroxyethylaminophenol (CAS 55302-96-0) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 2-Methyl-5-Hydroxyethylaminophenol →

SOURCE NOAEL studies
NOAEL studies
19
SOURCE Chemical inventory jurisdictions
Regulatory lists
4
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 11 fields
Name
2-Methyl-5-hydroxyethylaminophenol
CAS Number
55302-96-0
Molecular Formula
C9H13NO2
InChI Key
YGRFRBUGAPOJDU-UHFFFAOYSA-N
Monoisotopic Mass
167.094629
Synonyms
EINECS 259-583-72-Hydroxy-4-(beta-hydroxyethyl)aminotoluene6-Methyl-3-beta-hydroxyethylaminophenol1-Methyl-2-hydroxy-4-(beta-hydroxyethyl)aminobenzeneUNII-T872B9E83J5-((2-Hydroxyethyl)amino)-2-methylphenol

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records
ListKeywordSource
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 19 of 19 studies
ValueUnitEndpointRouteSpeciesSource
1000mg/kg bw/d-oralhumanRegulatory source
=7.8mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
0.4%EC3DermalMouseNTP ICE skin sensitization
T872B9E83JUNIIFDA UNII substance identifier--openFDA substances
50mg/kg bw/dayLOAELoralratCOSMOS DB
=0.053mg/kgNOAELoralratSCCS Opinion
=220mg/kg bw/dayNOAELoralRatECHA
=220mg/kg bwNOAELoral-SCCS Opinion
=220mg/kgNOAELoralratSCCS Opinion
=1000mg/kg bw/dayNOAELoralRatECHA
=1000mg/kg bw/dNOAELoralhumanSCCS Opinion
=1800mg/kg bw/dNOAELoralratSCCS Opinion
>2000mg/kg bwNOAEL-ratSCCS Opinion
=0.053mg/kgdermal absorptionoralratRegulatory source
=220mg/kgdermal absorptionoralratRegulatory source
1800mg/kg bw/ddevelopmental toxicityoralratRegulatory source
220mg/kg bwrepeated dose toxicityoral-Regulatory source
220mg/kg bwrepeated dose toxicity-ratRegulatory source
>2000mg/kg bwrepeated dose toxicity-ratRegulatory source

Showing 19 of 19 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registered5-[(2-hydroxyethyl)amino]-o-cresol259-583-7ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/0907/0528 March 2006safe1.0%sensitisation not excluded
SCCP/0957/052006-03-28The SCCP is of the opinion that the use of 2-methyl-5-hydroxyethylaminophenol itself as an oxidative hair dye at a maximum concentration of 1.5 % in the finished cosmetic product (after mixing with hydrogen peroxide) does not pose a risk to the health of the consumer.1.5%As a secondary amine it is prone to nitrosation; should not be used in combination with nitrosating substances; nitrosamine content should be < 50 ppb. Genotoxicity/mutagenicity studies on finished hair dye formulations should be undertaken per relevant SCCNFP opinions and Notes of Guidance.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
1.5%
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for 2-Methyl-5-hydroxyethylaminophenol?

2-Methyl-5-hydroxyethylaminophenol has 19 NOAEL studies in the database. The lowest reported value is 0.053 mg/kg via oral in rat. Source: SCCS Opinion.

What regulatory lists include 2-Methyl-5-hydroxyethylaminophenol?

2-Methyl-5-hydroxyethylaminophenol appears on 2 regulatory/inventory lists including Europe; Personal care - hair coloring, Europe; Personal care; restricted. Source: EPA CPDat.

Is 2-Methyl-5-hydroxyethylaminophenol used in cosmetics?

Yes, 2-Methyl-5-hydroxyethylaminophenol is also indexed as a cosmetic ingredient under the name 2-Methyl-5-Hydroxyethylaminophenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Methyl-5-hydroxyethylaminophenol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Methyl-5-hydroxyethylaminophenol have different safety status in cosmetics vs industrial chemicals?

2-Methyl-5-hydroxyethylaminophenol is prohibited in EU cosmetics at max 1.5% but has active industrial GHS classifications (H315, H319, H335, H411).

Is 2-Methyl-5-hydroxyethylaminophenol used outside industrial chemicals?

2-Methyl-5-hydroxyethylaminophenol also appears in cosmetics databases.