NOAEL Data REACH Registered Cosmetic Ingredient

2-Methyl-5-hydroxyethylaminophenol

Also known as: EINECS 259-583-7, 2-Hydroxy-4-(beta-hydroxyethyl)aminotoluene, 6-Methyl-3-beta-hydroxyethylaminophenol, 1-Methyl-2-hydroxy-4-(beta-hydroxyethyl)aminobenzene, UNII-T872B9E83J (+1 more)

CAS 55302-96-0

2-Methyl-5-hydroxyethylaminophenol (CAS 55302-96-0) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 2-Methyl-5-Hydroxyethylaminophenol →

Cross-Vertical Regulatory Divergence

2-Methyl-5-hydroxyethylaminophenol is prohibited in EU cosmetics at max 1.5% but has active industrial GHS classifications (H315, H319, H335, H411).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields

Name

2-Methyl-5-hydroxyethylaminophenol

CAS Number

55302-96-0

DTXSID

DTXSID70203849

Molecular Formula

C9H13NO2

InChI Key

YGRFRBUGAPOJDU-UHFFFAOYSA-N

Monoisotopic Mass

167.094629

Synonyms

EINECS 259-583-72-Hydroxy-4-(beta-hydroxyethyl)aminotoluene6-Methyl-3-beta-hydroxyethylaminophenol1-Methyl-2-hydroxy-4-(beta-hydroxyethyl)aminobenzeneUNII-T872B9E83J5-((2-Hydroxyethyl)amino)-2-methylphenol

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records

List	Keyword	Source
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care; restricted	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 45 of 45 studies

Value	Unit	Endpoint	Route	Species	Source
1000	mg/kg bw/d	-	oral	human	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=7.8	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
0.4	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
0.4	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
0.4	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
0.4	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
T872B9E83J	UNII	FDA UNII substance identifier	-	-	openFDA substances
T872B9E83J	UNII	FDA UNII substance identifier	-	-	openFDA substances
T872B9E83J	UNII	FDA UNII substance identifier	-	-	openFDA substances
T872B9E83J	UNII	FDA UNII substance identifier	-	-	openFDA substances
50	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=0.053	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.053	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.053	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.053	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=220	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=220	mg/kg bw	NOAEL	oral	-	SCCS_vision_codex
=220	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=220	mg/kg bw	NOAEL	oral	-	SCCS_vision_codex
=220	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=220	mg/kg bw	NOAEL	oral	-	SCCS_vision_codex
=220	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=220	mg/kg bw	NOAEL	oral	-	SCCS_vision_codex
=220	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1000	mg/kg bw/d	NOAEL	oral	human	SCCS_vision_codex
=1000	mg/kg bw/d	NOAEL	oral	human	SCCS_vision_codex
=1000	mg/kg bw/d	NOAEL	oral	human	SCCS_vision_codex
=1000	mg/kg bw/d	NOAEL	oral	human	SCCS_vision_codex
=1800	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=1800	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=1800	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=1800	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
>2000	mg/kg bw	NOAEL	-	rat	SCCS_vision_codex
>2000	mg/kg bw	NOAEL	-	rat	SCCS_vision_codex
>2000	mg/kg bw	NOAEL	-	rat	SCCS_vision_codex
>2000	mg/kg bw	NOAEL	-	rat	SCCS_vision_codex
=0.053	mg/kg	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=220	mg/kg	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=220	mg/kg	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1800	mg/kg bw/d	developmental toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1800	mg/kg bw/d	developmental toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
220	mg/kg bw	repeated dose toxicity	oral	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
220	mg/kg bw	repeated dose toxicity	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
>2000	mg/kg bw	repeated dose toxicity	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 45 of 45 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	5-[(2-hydroxyethyl)amino]-o-cresol	259-583-7	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/0907/05	28 March 2006	safe	1.0%	sensitisation not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

1.5%

Frequently Asked Questions

What is the NOAEL for 2-Methyl-5-hydroxyethylaminophenol?

2-Methyl-5-hydroxyethylaminophenol has 45 NOAEL studies in the database. The lowest reported value is 0.053 mg/kg via oral in rat. Source: SCCS_vision_codex.

What regulatory lists include 2-Methyl-5-hydroxyethylaminophenol?

2-Methyl-5-hydroxyethylaminophenol appears on 2 regulatory/inventory lists including Europe; Personal care - hair coloring, Europe; Personal care; restricted. Source: EPA CPDat.

Is 2-Methyl-5-hydroxyethylaminophenol used in cosmetics?

Yes, 2-Methyl-5-hydroxyethylaminophenol is also indexed as a cosmetic ingredient under the name 2-Methyl-5-Hydroxyethylaminophenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Methyl-5-hydroxyethylaminophenol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Methyl-5-hydroxyethylaminophenol have different safety status in cosmetics vs industrial chemicals?

2-Methyl-5-hydroxyethylaminophenol is prohibited in EU cosmetics at max 1.5% but has active industrial GHS classifications (H315, H319, H335, H411).

Is 2-Methyl-5-hydroxyethylaminophenol used outside industrial chemicals?

2-Methyl-5-hydroxyethylaminophenol also appears in cosmetics databases.