Also known as: EINECS 259-583-7, 2-Hydroxy-4-(beta-hydroxyethyl)aminotoluene, 6-Methyl-3-beta-hydroxyethylaminophenol, 1-Methyl-2-hydroxy-4-(beta-hydroxyethyl)aminobenzene, UNII-T872B9E83J (+1 more)
INCI: 2-METHYL-5-HYDROXYETHYLAMINOPHENOL
2-Methyl-5-Hydroxyethylaminophenol (CAS 55302-96-0) is a cosmetic cosmetic ingredient functioning as Hair dyeing (oxidative coupler). NOAEL 220 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited, max 1.5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 55302-96-0 →
2-Methyl-5-Hydroxyethylaminophenol is prohibited in EU cosmetics at max 1.5% but has active industrial GHS classifications (H315, H319, H335, H411).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Methyl-5-Hydroxyethylaminophenol.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for 2-Methyl-5-Hydroxyethylaminophenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.053 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.053 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.053 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.053 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =220 mg/kg bw | oral | - | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =220 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =220 mg/kg bw | oral | - | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =220 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =220 mg/kg bw | oral | - | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =220 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
Pre-calculated NOAEL → SED → MoS audit trail for 2-Methyl-5-Hydroxyethylaminophenol across SCCS product categories, with measured dermal absorption where available.
Contact sensitization data for 2-Methyl-5-Hydroxyethylaminophenol based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 3 | Oxidative hair dye products |
| BR | permitted_hair_dye | - | Oxidative hair dye |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 96.8% | - | - | SCCP/0040 |
| measured | 94.4% | - | - | SCCP/0040 |
| measured | 0.42% | - | - | SCCP/0040 |
| measured | 0.95% | - | - | SCCP/0040 |
2 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for 2-Methyl-5-Hydroxyethylaminophenol.
Public NOAEL study rows linked to 2-Methyl-5-Hydroxyethylaminophenol by CAS number or substance name.
Units vary across source rows: mg/kg, mg/kg bw/day, mg/kg bw
| Absorption % | Method | Vehicle |
|---|---|---|
| 96.8% | - | - |
| 94.4% | - | - |
| 0.42% | - | - |
| 0.95% | - | - |
2-Methyl-5-Hydroxyethylaminophenol has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
2-Methyl-5-Hydroxyethylaminophenol EU regulatory status: prohibited. Maximum allowed concentration: 1.5%. This is based on EU Regulation 1223/2009 and its amendments.
2-Methyl-5-Hydroxyethylaminophenol functions as: Hair dyeing (oxidative coupler). It is classified as a cosmetic ingredient in our database. CAS number: 55302-96-0.
The NOAEL (No Observed Adverse Effect Level) for 2-Methyl-5-Hydroxyethylaminophenol is =0.053 mg/kg based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
2-Methyl-5-Hydroxyethylaminophenol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
2-Methyl-5-Hydroxyethylaminophenol is prohibited in EU cosmetics at max 1.5% but has active industrial GHS classifications (H315, H319, H335, H411).
Check 2-Methyl-5-Hydroxyethylaminophenol compliance across multiple jurisdictions:
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