What is the NOAEL for 4-(1,3-Benzodioxol-5-yl)butan-2-one?
4-(1,3-Benzodioxol-5-yl)butan-2-one has 7 NOAEL studies in the database. The lowest reported value is 081VVC9H34 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
4-(1,3-Benzodioxol-5-yl)butan-2-one
Also known as: 4-Benzo(1,3)dioxol-5-yl-butan-2-one, 2-Butanone, 4-(1,3-benzodioxol-5-yl)-, Piperonyl acetone, EINECS 259-630-1, FEMA No. 2701 (+2 more)
CAS 55418-52-5
4-(1,3-Benzodioxol-5-yl)butan-2-one (CAS 55418-52-5) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
NOAEL studies
NOAEL studies
7
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
4-(1,3-Benzodioxol-5-yl)butan-2-one
CAS Number
55418-52-5
Molecular Formula
C11H12O3
InChI Key
TZJLGGWGVLADDN-UHFFFAOYSA-N
Monoisotopic Mass
192.078644
Synonyms
4-Benzo(1,3)dioxol-5-yl-butan-2-one2-Butanone, 4-(1,3-benzodioxol-5-yl)-Piperonyl acetoneEINECS 259-630-1FEMA No. 2701NSC 405365UNII-081VVC9H34
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 081VVC9H34 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 2362 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 66.1 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| 4 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 7 of 7 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL3184992
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 4-(1,3-Benzodioxol-5-yl)butan-2-one?
4-(1,3-Benzodioxol-5-yl)butan-2-one appears on 3 regulatory/inventory lists including IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Europe. Source: EPA CPDat.
Is 4-(1,3-Benzodioxol-5-yl)butan-2-one used in cosmetics?
Yes, 4-(1,3-Benzodioxol-5-yl)butan-2-one is also indexed as a cosmetic ingredient under the name Piperonyl Acetone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-(1,3-Benzodioxol-5-yl)butan-2-one come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 4-(1,3-Benzodioxol-5-yl)butan-2-one used outside industrial chemicals?
4-(1,3-Benzodioxol-5-yl)butan-2-one also appears in cosmetics, pharmaceutical databases.