Is Piperonyl Acetone safe in cosmetics?
Piperonyl Acetone has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Piperonyl Acetone
Also known as: 4-Benzo(1,3)dioxol-5-yl-butan-2-one, 2-Butanone, 4-(1,3-benzodioxol-5-yl)-, EINECS 259-630-1, FEMA No. 2701, NSC 405365 (+1 more)
INCI: PIPERONYL ACETONE
Piperonyl Acetone (CAS 55418-52-5) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 55418-52-5 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
4-(1,3-benzodioxol-5-yl)butan-2-one
InChIKey
TZJLGGWGVLADDN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted; general cosmetic safety requirements apply
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Piperonyl Acetone.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
2362 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [244] Epstein WL (1974): Report to RIFM, 27 August, unpublished.
HRIPT Human Patch Test Studies
3 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 106 | 0 | 2362 | 2362 | non-sensitizer |
| HMT | - | 0 | 2592 | - | - |
| HRIPT | - | 0 | 2362 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
2048
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
4-(3,4-METHYLENEDIOXYPHENYL)-2-BUTANONE | 2010 | No safety concern at current levels of intake when used as a flavouring agent | TRS 960-JECFA 73/101 | FAS 64-JECFA 73/157
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Piperonyl Acetone.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
4-Benzo(1,3)dioxol-5-yl-butan-2-one
2-Butanone, 4-(1,3-benzodioxol-5-yl)-
EINECS 259-630-1
FEMA No. 2701
NSC 405365
UNII-081VVC9H34
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184992
Frequently Asked Questions
Is Piperonyl Acetone allowed in the EU?
Piperonyl Acetone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Piperonyl Acetone do in cosmetics?
Piperonyl Acetone functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 55418-52-5.
Is Piperonyl Acetone used outside cosmetics?
Piperonyl Acetone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Piperonyl Acetone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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