NOAEL Data REACH Registered Cosmetic Ingredient

Acesulfame potassium

Also known as: 6-Methyl-1,2,3-oxathiazin-4(3h)-one 2,2-dioxide potassium salt, Potassium 3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide, Potassium acesulfame, Acesulfam-K, EINECS 259-715-3 (+1 more)

CAS 55589-62-3

Acesulfame potassium (CAS 55589-62-3) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Potassium Acesulfame →

SOURCE NOAEL studies
NOAEL studies
38
SOURCE Chemical inventory jurisdictions
Regulatory lists
2
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 11 fields
Name
Acesulfame potassium
CAS Number
55589-62-3
Molecular Formula
C4H5NO4S.K
InChI Key
WBZFUFAFFUEMEI-UHFFFAOYSA-M
Monoisotopic Mass
201.957635
Synonyms
6-Methyl-1,2,3-oxathiazin-4(3h)-one 2,2-dioxide potassium saltPotassium 3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxidePotassium acesulfameAcesulfam-KEINECS 259-715-3Acesulfame-potassium

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 15 records
DeodorizerFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records
ListKeywordSource
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
inert_ingredient; non_food_use; PesticidesEPACPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 38 of 38 studies
ValueUnitEndpointRouteSpeciesSource
=9mg/kg bw/dayADI-ConsumersEFSA
=450mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
23OV73Q5G9UNIIFDA UNII substance identifier--openFDA substances
=5438mg/kg bwLD50oralRatNTP ICE acute oral
=5565mg/kg bwLD50oralRatNTP ICE acute oral
=7431mg/kg bwLD50oralRatNTP ICE acute oral
=1.018e+4mg/kg bwLD50oralRatNTP ICE acute oral
1.000e+4mg/kg bw/dayLOAELoralratCOSMOS DB
0unitlessModel Score--NTP ICE endocrine
300mg/kg bw/dayNOAELoralratCOSMOS DB
>600mg/kg bw/dayNOAELoralDogECHA
750mg/kg bw/dayNOAELoraldogCOSMOS DB
900mg/kg bw/dayNOAELoralrabbitCOSMOS DB
1500mg/kg bw/dayNOAELoralratCOSMOS DB
>1850mg/kg bw/dayNOAELoralMouseECHA
>2340mg/kg bw/dayNOAELoralRatECHA
>=2880mg/kg bw/dayNOAELoralRatECHA
3000mg/kg bw/dayNOAELoralratCOSMOS DB
4500mg/kg bw/dayNOAELoralmouseCOSMOS DB
4700mg/kg bw/dayNOAELoralmouseCOSMOS DB
5543mg/kg bw/dayNOAELoralratCOSMOS DB
>5550mg/kg bw/dayNOAELoralMouseECHA
5571mg/kg bw/dayNOAELoralratCOSMOS DB
5652mg/kg bw/dayNOAELoralratCOSMOS DB
5673mg/kg bw/dayNOAELoralratCOSMOS DB
5691mg/kg bw/dayNOAELoralratCOSMOS DB
5863mg/kg bw/dayNOAELoralratCOSMOS DB
6922mg/kg bw/dayNOAELoralratCOSMOS DB
7072mg/kg bw/dayNOAELoralratCOSMOS DB
7078mg/kg bw/dayNOAELoralratCOSMOS DB
7222mg/kg bw/dayNOAELoralratCOSMOS DB
7983mg/kg bw/dayNOAELoralratCOSMOS DB
8251mg/kg bw/dayNOAELoralratCOSMOS DB
1.000e+4mg/kg bw/dayNOAELoralratCOSMOS DB
=1.000e+4ppmNOAELoralRatECHA
>3.000e+4ppmNOAELoralRatECHA
=900mg/kg bw/dayNOELoralRabbitECHA
=2000mg/kg bw/dayNOELoralMouseToxValDB ECOTOX

Showing 38 of 38 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registered6-methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide, potassium salt259-715-3ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed ACESULFAME POTASSIUM
ChEMBL Phase
3
Adverse Events
0
Bioactivity
2
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

E950 — ADI: 15 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Acesulfame potassium?

Acesulfame potassium has 38 NOAEL studies in the database. The lowest reported value is 9 mg/kg bw/day in Consumers. Source: EFSA.

What regulatory lists include Acesulfame potassium?

Acesulfame potassium appears on 2 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.

Is Acesulfame potassium used in cosmetics?

Yes, Acesulfame potassium is also indexed as a cosmetic ingredient under the name Potassium Acesulfame. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Acesulfame potassium come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Acesulfame potassium used outside industrial chemicals?

Acesulfame potassium also appears in cosmetics, pharmaceutical, food safety, cannabis databases.