NOAEL Data REACH Registered Cosmetic Ingredient

Zinc acetate

Also known as: ZnOAc2, EINECS 209-170-2, NSC 75801, UNII-H2ZEY72PME, Acetic acid, zinc(II) salt (+4 more)

CAS 557-34-6

Zinc acetate (CAS 557-34-6) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for ZINC ACETATE →

SOURCE NOAEL studies
NOAEL studies
87
SOURCE Chemical inventory jurisdictions
Regulatory lists
9
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 15 fields
Name
Zinc acetate
CAS Number
557-34-6
DTXSID
DTXSID8038770
Molecular Formula
2C2H4O2.Zn
InChI Key
DJWUNCQRNNEAKC-UHFFFAOYSA-L
Monoisotopic Mass
183.971401
Synonyms
ZnOAc2EINECS 209-170-2NSC 75801UNII-H2ZEY72PMEAcetic acid, zinc(II) saltDicarbomethoxyzincZinc acetate anhydrousZn(II)Ac2Zn(OAc)2

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 16 records
BiocideHumectantAstringentStabilizing agentFoamantCatalyst

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 9 records
ListKeywordSource
Canada; consumer_product; Substances in Products - Canada (4/2014)Government of CanadaCPCat
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
active_ingredient; animal_products; Europe; pharmaceutical; residueEUCPCat
Europe; supplementsEUCPCat
Europe; food_additive; supplementsEUCPCat
Europe; pharmaceuticalEuropean Medicines AgencyPROTECT ADR database
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 87 studies
ValueUnitEndpointRouteSpeciesSource
0.1%-oral-Regulatory source
0.43--oral-Regulatory source
0.43--oral-Regulatory source
1%-oral-Regulatory source
1%-oral-Regulatory source
6--oral-Regulatory source
10----Regulatory source
10----Regulatory source
10----Regulatory source
16----Regulatory source
16----Regulatory source
16----Regulatory source
17--oral-Regulatory source
24----Regulatory source
24----Regulatory source
24----Regulatory source
24----Regulatory source
37----Regulatory source
37----Regulatory source
37----Regulatory source
37----Regulatory source
50----Regulatory source
50----Regulatory source
50----Regulatory source
53----Regulatory source
1657--oral-Regulatory source
=4.71mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
H2ZEY72PMEUNIIFDA UNII substance identifier--openFDA substances
H2ZEY72PMEUNIIFDA UNII substance identifier--openFDA substances
H2ZEY72PMEUNIIFDA UNII substance identifier--openFDA substances
H2ZEY72PMEUNIIFDA UNII substance identifier--openFDA substances
=136mg/kg bw/dayLOAELoralMouseECHA
=0.1mg/mLLOELoralMouseToxValDB ECOTOX
=20% w/vLOELdermalMouseToxValDB ECOTOX
=5000mg/kg bw/dayLOELoralRatToxValDB ECOTOX
=0.1%NOAELoral-SCCS Opinion
=0.1%NOAELoral-SCCS Opinion
=0.1%NOAELoral-SCCS Opinion
=0.1%NOAELoral-SCCS Opinion
=0.43-NOAELoral-SCCS Opinion
=0.43-NOAELoral-SCCS Opinion
=0.43-NOAELoral-SCCS Opinion
=0.43-NOAELoral-SCCS Opinion
=1%NOAELoral-SCCS Opinion
=1%NOAELoral-SCCS Opinion
=1%NOAELoral-SCCS Opinion
=1%NOAELoral-SCCS Opinion
=6-NOAELoral-SCCS Opinion
=6-NOAELoral-SCCS Opinion
=6-NOAELoral-SCCS Opinion

Showing 50 of 87 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredZinc di(acetate)209-170-2ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
III/24
Category
Preservatives
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed ZINC ACETATE ANHYDROUS
ChEMBL Phase
4
Adverse Events
12
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for Zinc acetate?

Zinc acetate has 87 NOAEL studies in the database. The lowest reported value is 0.1 % via oral. Source: Regulatory source.

What regulatory lists include Zinc acetate?

Zinc acetate appears on 8 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), pharmaceutical, active_ingredient; animal_products; Europe; pharmaceutical; residue, and 5 more. Source: EPA CPDat.

Is Zinc acetate used in cosmetics?

Yes, Zinc acetate is also indexed as a cosmetic ingredient under the name ZINC ACETATE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Zinc acetate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Zinc acetate have different safety status in cosmetics vs industrial chemicals?

Zinc acetate is classified GHS Danger (H302, H318, H319, H400, H410, H411) in the chemicals database but is restricted in EU cosmetics at max III/24.

Is Zinc acetate used outside industrial chemicals?

Zinc acetate also appears in cosmetics, pharmaceutical databases.