Also known as: ZnOAc2, EINECS 209-170-2, NSC 75801, UNII-H2ZEY72PME, Acetic acid, zinc(II) salt (+4 more)
ZINC ACETATE (CAS 557-34-6) is a cosmetic cosmetic ingredient functioning as Antimicrobial. Reported NOAEL =50 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: restricted, max III/24; 2 safety opinions reviewed (SCCS Opinion). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
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Toxicological Studies
1 study endpoint found for ZINC ACETATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=50 mg/kg bw/day
oral
Rat
reproduction developmental
ECHA
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
SCCS OpinionSCCS/1657/2326 October 2023
Verdict: unknown
Max Concentration: 1% in general
SCCS OpinionSCCS/1657/2326 October 2023
Verdict: unknown
Max Concentration: 1% in oral care
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Additional Ingredient Properties
3 property records from structured ingredient metadata.
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Evidence for Carcinogenicity
CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: Based on inadequate evidence in humans and animals. HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: Inadequate. /Zinc and compounds/
Source: Hazardous Substances Data Bank (HSDB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Skin Eye Respiratory Irritation
Zinc salts of strong mineral acids are astringent, corrosive to skin ... /Zinc salts/ | The dust is irritating to eyes, nose and throat. The solid is irritating to skin and eyes.
ZINC ACETATE has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 1 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by SCCS Opinion.
Is ZINC ACETATE allowed in the EU?
ZINC ACETATE EU regulatory status: restricted. Maximum allowed concentration: III/24. This is based on EU Regulation 1223/2009 and its amendments.
What does ZINC ACETATE do in cosmetics?
ZINC ACETATE functions as: Antimicrobial. It is classified as a cosmetic ingredient in our database. CAS number: 557-34-6.
What is the NOAEL for ZINC ACETATE?
The NOAEL (No Observed Adverse Effect Level) for ZINC ACETATE is =50 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ECHA.
Is ZINC ACETATE used outside cosmetics?
ZINC ACETATE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does ZINC ACETATE have different safety status in cosmetics vs industrial chemicals?
ZINC ACETATE is classified GHS Danger (H302, H318, H319, H400, H410, H411) in the chemicals database but is restricted in EU cosmetics at max III/24.
Compliance Tools
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