What is the NOAEL for L-Glutamic acid?
L-Glutamic acid has 12 NOAEL studies in the database. The lowest reported value is 10 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
L-Glutamic acid
Also known as: Acidum glutaminicum, L-2-Aminoglutaric acid, 2-Aminopentanedioic acid, (S)-, EINECS 200-293-7, FEMA No. 3285 (+15 more)
CAS 56-86-0
L-Glutamic acid (CAS 56-86-0) is a chemical substance. Key regulatory status: REACH registered, 17 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
L-Glutamic acid is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
17
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
L-Glutamic acid
CAS Number
56-86-0
DTXSID
DTXSID5020659
Molecular Formula
C5H9NO4
InChI Key
WHUUTDBJXJRKMK-VKHMYHEASA-N
Monoisotopic Mass
147.053158
Synonyms
Acidum glutaminicumL-2-Aminoglutaric acid2-Aminopentanedioic acid, (S)-EINECS 200-293-7FEMA No. 3285Glutamate, L-Glutamic acid (H-3)Glutamic acid, (S)-D-GlutamiensuurEPA Pesticide Chemical Code 374350Acidum glutamicumUNII-3KX376GY7L
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
HumectantAnti-static agentSoftener and conditionerpH regulating agentFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
17 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| active_ingredient; agricultural; applied; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; applied; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| Canada; pharmaceutical | DrugBank | DrugBank |
| active_ingredient; agricultural; applied; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; applied; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; applied; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; applied; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =30 | mg/kg bw/day | ADI (group) | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =30 | mg/kg bw/day | ADI (group) | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =10 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3KX376GY7L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3KX376GY7L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3KX376GY7L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3KX376GY7L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =3200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =3200 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =3200 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 5000 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 10000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Glutamic acid | 200-293-7 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
humectant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
GLUTAMIC ACID
ChEMBL Phase
3
Adverse Events
2
Bioactivity
48
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E620 — ADI: 30 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Glutamic acid?
L-Glutamic acid appears on 8 regulatory/inventory lists including active_ingredient; Europe; Pesticides, active_ingredient; agricultural; applied; Pesticides, Canada; pharmaceutical, and 5 more. Source: EPA CPDat.
Is L-Glutamic acid used in cosmetics?
Yes, L-Glutamic acid is also indexed as a cosmetic ingredient under the name L-Glutamic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Glutamic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does L-Glutamic acid have different safety status in cosmetics vs industrial chemicals?
L-Glutamic acid is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics.
Is L-Glutamic acid used outside industrial chemicals?
L-Glutamic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.