Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for L-Glutamic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 5000 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 10000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 5000 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| dose_tested | 10000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
L-Glutamic acid is a precursor to the skin's dominant NMF component. EU-approved for cosmetic use, FDA GRAS, CIR-assessed safe. No restrictions at cosmetic use levels.
Regulatory Flags
Frequently Asked Questions
Is L-Glutamic Acid safe in cosmetics?
L-Glutamic acid is a precursor to the skin's dominant NMF component. EU-approved for cosmetic use, FDA GRAS, CIR-assessed safe. No restrictions at cosmetic use levels. The EU classifies L-Glutamic Acid as "permitted". Safety rating: EXCELLENT. 5 toxicological study endpoint(s) are available in our database.
Is L-Glutamic Acid allowed in the EU?
L-Glutamic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does L-Glutamic Acid do in cosmetics?
L-Glutamic Acid functions as: Enzymatically converts to pyrrolidone carboxylic acid (PCA), the largest single component of the skin's natural moisturizing factor (NMF). Ion-pair formulations with L-arginine enhance percutaneous absorption.. It is classified as a Humectant in our database. CAS number: 56-86-0.
What is the Margin of Safety for L-Glutamic Acid?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for L-Glutamic Acid?
The NOAEL (No Observed Adverse Effect Level) for L-Glutamic Acid is 5000 mg/kg bw/day based on a Developmental study via oral route in mouse. A total of 5 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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