What is the NOAEL for Chlorhexidine diacetate?
Chlorhexidine diacetate has 25 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP ICE adme parameters.
NOAEL Data
Cosmetic Ingredient
Chlorhexidine diacetate
Also known as: Chlorohexidine diacetate, Tetraazatetradecanediimidamide, N,N′′-bis(4-chlorophenyl)-3,12-diimino-, diacetate, Biguanide, 1,1′-hexamethylenebis[5-(p-chlorophenyl)-, diacetate 2,4,11,13-, 2,4,11,13-Tetraazatetradecanediimidamide, N,N′′-bis(4-chlorophenyl)-3,12-diimino-, acetate (1:2), 10,040 Diacetate (+15 more)
CAS 56-95-1
Chlorhexidine diacetate (CAS 56-95-1) is a chemical substance. Key regulatory status: 23 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
Cross-Vertical Regulatory Divergence
Chlorhexidine diacetate is classified GHS Danger (H317, H318, H334, H301, H302, H319, H400, H410) in the chemicals database but is restricted in EU cosmetics at max V/42.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
25
SOURCE
Chemical inventory jurisdictions
Regulatory lists
23
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Chlorhexidine diacetate
CAS Number
56-95-1
DTXSID
DTXSID7032345
Molecular Formula
C22H30Cl2N10.2C2H4O2
InChI Key
WDRFFJWBUDTUCA-UHFFFAOYSA-N
Monoisotopic Mass
624.245455
Synonyms
Chlorohexidine diacetateTetraazatetradecanediimidamide, N,N′′-bis(4-chlorophenyl)-3,12-diimino-, diacetateBiguanide, 1,1′-hexamethylenebis[5-(p-chlorophenyl)-, diacetate 2,4,11,13-2,4,11,13-Tetraazatetradecanediimidamide, N,N′′-bis(4-chlorophenyl)-3,12-diimino-, acetate (1:2)10,040 DiacetateBactigras1,6-Bis(5-(p-chlorophenyl)biguandino)hexane diacetate1,6-Bis(p-chlorophenylbiguanido)hexane diacetateBis(p-chlorophenyldiguanidohexane) diacetateCaswell No. 481EChlorhexidine acetate1,6-Di(4'-chlorophenyldiguanidino)hexane diacetate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
BiocidePreservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
23 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 25 of 25 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 10.9076577282612 | uM | AC50 | - | - | NTP ICE endocrine |
| 18.6858414673904 | uM | AC50 | - | - | NTP ICE endocrine |
| 10.4480936495262 | uM | ACC | - | - | NTP ICE endocrine |
| 19.0921883106424 | uM | ACC | - | - | NTP ICE endocrine |
| - | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 5908ZUF22Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5908ZUF22Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5908ZUF22Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5908ZUF22Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.00236 | fraction | Fu | - | Human | NTP ICE adme parameters |
| =15.63 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =15.63 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Sprague Dawley (CD)) | EPA ToxRefDB v3 |
| >62.5 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| >62.5 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Sprague Dawley (CD)) | EPA ToxRefDB v3 |
| =250 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =250 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Sprague Dawley SD) | EPA ToxRefDB v3 |
| >2000 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| >2000 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Sprague Dawley SD) | EPA ToxRefDB v3 |
| =31.25 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB ToxRefDB |
| =31.25 | mg/kg bw/day | LOAEL | oral | rat (sprague dawley; Sprague Dawley (CD)) | EPA ToxRefDB v3 |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.00201 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.132 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.305 | unitless | Model Score | - | - | NTP ICE endocrine |
| >- | mg/kg bw/day | NEL | oral | rat (sprague dawley; Sprague Dawley SD) | EPA ToxRefDB v3 |
Showing 25 of 25 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
V/42
Category
Preservatives
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHLORHEXIDINE DIACETATE
ChEMBL Phase
3
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What regulatory lists include Chlorhexidine diacetate?
Chlorhexidine diacetate appears on 4 regulatory/inventory lists including active_ingredient; Pesticides, active_ingredient; Australia, inert_ingredient; non_food_use; Pesticides, and 1 more. Source: EPA CPDat.
Is Chlorhexidine diacetate used in cosmetics?
Yes, Chlorhexidine diacetate is also indexed as a cosmetic ingredient under the name CHLORHEXIDINE DIACETATE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Chlorhexidine diacetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Chlorhexidine diacetate have different safety status in cosmetics vs industrial chemicals?
Chlorhexidine diacetate is classified GHS Danger (H317, H318, H334, H301, H302, H319, H400, H410) in the chemicals database but is restricted in EU cosmetics at max V/42.
Is Chlorhexidine diacetate used outside industrial chemicals?
Chlorhexidine diacetate also appears in cosmetics, pharmaceutical databases.