What is the NOAEL for 2,6-Dimethoxy-3,5-pyridinediamine HCl?
2,6-Dimethoxy-3,5-pyridinediamine HCl has 26 NOAEL studies in the database. The lowest reported value is 6.9 % via Dermal in Mouse. Source: NTP_ICE_skin_sensitization.
NOAEL Data
Cosmetic Ingredient
2,6-Dimethoxy-3,5-pyridinediamine HCl
CAS 56216-28-5
2,6-Dimethoxy-3,5-pyridinediamine HCl (CAS 56216-28-5) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.
View cosmetic safety profile for 2,6-Dimethoxy-3,5-Pyridinediamine HCl →
Cross-Vertical Regulatory Divergence
2,6-Dimethoxy-3,5-pyridinediamine HCl is classified GHS Danger (H301, H317, H373, H319) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
26
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
6 fields
Name
2,6-Dimethoxy-3,5-pyridinediamine HCl
CAS Number
56216-28-5
DTXSID
DTXSID10892438
Molecular Formula
C7H11N3O2.4ClH
InChI Key
XQPQLPDJQXAADO-UHFFFAOYSA-N
Monoisotopic Mass
312.991837
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 26 of 26 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 45 | mg/kg bw | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 45 | mg/kg bw | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 6.9 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| H109UIY001 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H109UIY001 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H109UIY001 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H109UIY001 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 15 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| 5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =5 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =5 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =5 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =5 | mg/kg | NOAEL | dermal | human | SCCS_vision_codex |
| =10 | mg/kg bw | NOAEL | dermal | rabbit | SCCS_vision_codex |
| =10 | mg/kg bw | NOAEL | dermal | rabbit | SCCS_vision_codex |
| =10 | mg/kg bw | NOAEL | dermal | rabbit | SCCS_vision_codex |
| =10 | mg/kg bw | NOAEL | dermal | rabbit | SCCS_vision_codex |
| =45 | mg/kg bw | NOAEL | - | - | SCCS_vision_codex |
| =45 | mg/kg bw | NOAEL | - | - | SCCS_vision_codex |
| =45 | mg/kg bw | NOAEL | - | - | SCCS_vision_codex |
| =45 | mg/kg bw | NOAEL | - | - | SCCS_vision_codex |
| =5 | mg/kg | dermal absorption | dermal | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =5 | mg/kg | dermal absorption | dermal | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =5 | mg/kg | dermal absorption | dermal | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | mg/kg bw | dermal absorption | dermal | rabbit | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 45 | mg/kg bw | dermal absorption | dermal | rabbit | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
Showing 26 of 26 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/0878/05 | 20 September 2005 | safe | 0.5% | sensitisation not excluded |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Colorant
Frequently Asked Questions
Is 2,6-Dimethoxy-3,5-pyridinediamine HCl used in cosmetics?
Yes, 2,6-Dimethoxy-3,5-pyridinediamine HCl is also indexed as a cosmetic ingredient under the name 2,6-Dimethoxy-3,5-Pyridinediamine HCl. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,6-Dimethoxy-3,5-pyridinediamine HCl come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does 2,6-Dimethoxy-3,5-pyridinediamine HCl have different safety status in cosmetics vs industrial chemicals?
2,6-Dimethoxy-3,5-pyridinediamine HCl is classified GHS Danger (H301, H317, H373, H319) in the chemicals database but is restricted in EU cosmetics.
Is 2,6-Dimethoxy-3,5-pyridinediamine HCl used outside industrial chemicals?
2,6-Dimethoxy-3,5-pyridinediamine HCl also appears in cosmetics databases.