2,6-Dimethoxy-3,5-Pyridinediamine HCl
INCI: 2,6-DIMETHOXY-3,5-PYRIDINEDIAMINE HCL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for 2,6-Dimethoxy-3,5-Pyridinediamine HCl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 5 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 15 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Confirmed skin sensitizer with EC3 exceeding LLNA threshold; no skin irritation at 3% aqueous dilution.
Regulatory Flags
Frequently Asked Questions
Is 2,6-Dimethoxy-3,5-Pyridinediamine HCl safe in cosmetics?
Confirmed skin sensitizer with EC3 exceeding LLNA threshold; no skin irritation at 3% aqueous dilution. The EU classifies 2,6-Dimethoxy-3,5-Pyridinediamine HCl as "restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is 2,6-Dimethoxy-3,5-Pyridinediamine HCl allowed in the EU?
2,6-Dimethoxy-3,5-Pyridinediamine HCl EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,6-Dimethoxy-3,5-Pyridinediamine HCl do in cosmetics?
2,6-Dimethoxy-3,5-Pyridinediamine HCl functions as: Hair Dyeing (oxidative hair dye coupler). It is classified as a cosmetic ingredient in our database. CAS number: 56216-28-5.
What is the Margin of Safety for 2,6-Dimethoxy-3,5-Pyridinediamine HCl?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 2,6-Dimethoxy-3,5-Pyridinediamine HCl?
The NOAEL (No Observed Adverse Effect Level) for 2,6-Dimethoxy-3,5-Pyridinediamine HCl is 5 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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