INCI: 2,6-DIMETHOXY-3,5-PYRIDINEDIAMINE HCL
2,6-Dimethoxy-3,5-Pyridinediamine HCl (CAS 56216-28-5) is a cosmetic cosmetic ingredient functioning as Hair Dyeing (oxidative hair dye coupler). Reported NOAEL =5 mg/kg in human (SCCS Opinion); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 56216-28-5 →
2,6-Dimethoxy-3,5-Pyridinediamine HCl is classified GHS Danger (H301, H317, H373, H319) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for 2,6-Dimethoxy-3,5-Pyridinediamine HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for 2,6-Dimethoxy-3,5-Pyridinediamine HCl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =5 mg/kg | dermal | human | dermal absorption | SCCS Opinion |
| NOAEL | =5 mg/kg | dermal | human | dermal absorption | SCCS Opinion |
| NOAEL | =5 mg/kg | dermal | human | dermal absorption | SCCS Opinion |
| NOAEL | =5 mg/kg | dermal | human | dermal absorption | SCCS Opinion |
| NOAEL | =10 mg/kg bw | dermal | rabbit | dermal absorption | SCCS Opinion |
| NOAEL | =10 mg/kg bw | dermal | rabbit | dermal absorption | SCCS Opinion |
| NOAEL | =10 mg/kg bw | dermal | rabbit | dermal absorption | SCCS Opinion |
| NOAEL | =10 mg/kg bw | dermal | rabbit | dermal absorption | SCCS Opinion |
| NOAEL | =45 mg/kg bw | - | - | NOAEL study | SCCS Opinion |
| NOAEL | =45 mg/kg bw | - | - | NOAEL study | SCCS Opinion |
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 0.37% | - | - | SCCP/0908/05 |
| measured_sccs_opinion | 0.37% | - | - | SCCP/0908/05 |
| measured_sccs_opinion | 0.37% | - | - | SCCP/0908/05 |
Preliminary editorial summary for 2,6-Dimethoxy-3,5-Pyridinediamine HCl — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to 2,6-Dimethoxy-3,5-Pyridinediamine HCl by CAS number or substance name.
Units vary across source rows: mg/kg, mg/kg bw
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.37% | SCCS opinion extraction | - |
| 0.37% | SCCS opinion extraction | - |
| 0.37% | SCCS opinion extraction | - |
2,6-Dimethoxy-3,5-Pyridinediamine HCl has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
2,6-Dimethoxy-3,5-Pyridinediamine HCl EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
2,6-Dimethoxy-3,5-Pyridinediamine HCl functions as: Hair Dyeing (oxidative hair dye coupler). It is classified as a cosmetic ingredient in our database. CAS number: 56216-28-5.
The NOAEL (No Observed Adverse Effect Level) for 2,6-Dimethoxy-3,5-Pyridinediamine HCl is =5 mg/kg based on a dermal absorption study via dermal route in human. A total of 10 study endpoints are available. Source: SCCS Opinion.
2,6-Dimethoxy-3,5-Pyridinediamine HCl also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
2,6-Dimethoxy-3,5-Pyridinediamine HCl is classified GHS Danger (H301, H317, H373, H319) in the chemicals database but is restricted in EU cosmetics.
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