Danger GHS02 NOAEL Data Prop 65 REACH Registered Cosmetic Ingredient

3-Methyl-2-butanone

Also known as: Methyl isopropyl ketone, 2-Acetyl propane, Caswell No. 555A, EINECS 209-264-3, EPA Pesticide Chemical Code 044104 (+4 more)

CAS 563-80-4

3-Methyl-2-butanone (CAS 563-80-4) is a chemical substance with GHS signal word Danger; key hazard signal: H225. Key regulatory status: California Proposition 65, REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, CA Prop 65, ILO ICSC, OSHA.

View cosmetic safety profile for Methyl Isopropyl Ketone →

Cross-Vertical Regulatory Divergence

3-Methyl-2-butanone is classified GHS Danger (H225) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 15 fields

Name

3-Methyl-2-butanone

CAS Number

563-80-4

DTXSID

DTXSID0022062

Molecular Formula

C5H10O

InChI Key

SYBYTAAJFKOIEJ-UHFFFAOYSA-N

Monoisotopic Mass

86.073165

Synonyms

Methyl isopropyl ketone2-Acetyl propaneCaswell No. 555AEINECS 209-264-3EPA Pesticide Chemical Code 044104Ketone, isopropyl methylMethyl butanone-2MethylbutanoneUNII-V8DP6THY5O

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records

Chemical	Toxicity Type	Cancer	Developmental	Listed
-	developmental	No	Yes	-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 2	H225	GHS02	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Highly flammable liquid and vapour May be harmful if swallowed Causes eye irritation May be harmful if swallowed and enters airways
Short-term Effects	The substance is irritating to the eyes, skin and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. The substance may cause effects on the central nervous system. This may result in lowering of consciousness.
Long-term Effects	May cause skin dryness or cracking
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 2 records

Agency	Metric	Value	ppm	mg/m3	Skin
NIOSH	TWA	200 ppm (705 mg/m³)	200	705	N
ACGIH	TWA	20 ppm [2010]	20	-	N

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

FragranceFlavouring and nutrientSolvent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records

List	Keyword	Source
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Europe	European Commission	Fl@vis
air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 16 of 16 studies

Value	Unit	Endpoint	Route	Species	Source
LCdevelopmental	listing type	California Proposition 65 listing	-	-	California Proposition 65
LCdevelopmental	listing type	California Proposition 65 listing	-	-	California Proposition 65
LCdevelopmental	listing type	California Proposition 65 listing	-	-	California Proposition 65
LCdevelopmental	listing type	California Proposition 65 listing	-	-	California Proposition 65
=265.52	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
V8DP6THY5O	UNII	FDA UNII substance identifier	-	-	openFDA substances
V8DP6THY5O	UNII	FDA UNII substance identifier	-	-	openFDA substances
V8DP6THY5O	UNII	FDA UNII substance identifier	-	-	openFDA substances
V8DP6THY5O	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
6750	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
22.4513	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=148	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=3078	mg/kg bw	LD50	oral	Rat (Male/Female)	NTP_ICE_acute_oral
=4528	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 16 of 16 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	3-methylbutanone	209-264-3	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3183920

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 3-Methyl-2-butanone?

3-Methyl-2-butanone (CAS 563-80-4) is classified under EU CLP Annex VI as Flam. Liq. 2 with signal word Danger. Hazard statements: H225. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 3-Methyl-2-butanone?

3-Methyl-2-butanone has 16 NOAEL studies in the database. The lowest reported value is developmental listing type. Source: California Proposition 65.

What regulatory lists include 3-Methyl-2-butanone?

3-Methyl-2-butanone appears on 4 regulatory/inventory lists including air; detected; emissions; Europe; Other direct contact consumer goods, detected; Europe; Other direct contact consumer goods, Europe, and 1 more. Source: EPA CPDat.

Is 3-Methyl-2-butanone on the California Proposition 65 list?

Yes, 3-Methyl-2-butanone is listed under California Proposition 65 for developmental. Source: California OEHHA Proposition 65.

What are the occupational exposure limits for 3-Methyl-2-butanone?

Occupational exposure limits for 3-Methyl-2-butanone are set by NIOSH, ACGIH. 2 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 3-Methyl-2-butanone used in cosmetics?

Yes, 3-Methyl-2-butanone is also indexed as a cosmetic ingredient under the name Methyl Isopropyl Ketone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 3-Methyl-2-butanone come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 3-Methyl-2-butanone have different safety status in cosmetics vs industrial chemicals?

3-Methyl-2-butanone is classified GHS Danger (H225) in the chemicals database but is allowed in EU cosmetics.

Is 3-Methyl-2-butanone used outside industrial chemicals?

3-Methyl-2-butanone also appears in cosmetics, pharmaceutical, cannabis databases.