Moderate Cosmetic Ingredient GHS Classified

Methyl Isopropyl Ketone

INCI: METHYL ISOPROPYL KETONE (ALSO: 3-METHYL-2-BUTANONE)

CAS Number
563-80-4
Function
Solvent - primarily an industrial solvent with limited direct cosmetic application
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not specifically restricted for cosmetic use; more commonly regulated under industrial chemical frameworks

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
flam;flame; cancer;health haz
Hazard Statements
Highly flammable liquid and vapour May be harmful if swallowed Causes eye irritation May be harmful if swallowed and enters airways
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. The substance may cause effects on the central nervous system. This may result in lowering of consciousness.
Long-term Exposure Effects
May cause skin dryness or cracking
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.

Expert Verdict

Potential skin and eye irritant; inhalation hazard at high concentrations; limited dermal toxicity data for cosmetic contexts. Low molecular weight ketone; volatile; primarily used as a chemical intermediate and laboratory solvent rather than a finished-product cosmetic ingredient

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Concern Level: High

Frequently Asked Questions

Is Methyl Isopropyl Ketone safe in cosmetics?

Potential skin and eye irritant; inhalation hazard at high concentrations; limited dermal toxicity data for cosmetic contexts. Low molecular weight ketone; volatile; primarily used as a chemical intermediate and laboratory solvent rather than a finished-product cosmetic ingredient The EU classifies Methyl Isopropyl Ketone as "permitted". Safety rating: MODERATE.

Is Methyl Isopropyl Ketone allowed in the EU?

Methyl Isopropyl Ketone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl Isopropyl Ketone do in cosmetics?

Methyl Isopropyl Ketone functions as: Solvent - primarily an industrial solvent with limited direct cosmetic application. It is classified as a cosmetic ingredient in our database. CAS number: 563-80-4.

What is the Margin of Safety for Methyl Isopropyl Ketone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Is Methyl Isopropyl Ketone classified as hazardous under GHS?

Methyl Isopropyl Ketone carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour May be harmful if swallowed Causes eye irritation May be harmful if swallowed and enters airways. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance โ€” at cosmetic use concentrations, hazard thresholds may not be met.

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