Is Methyl Isopropyl Ketone safe in cosmetics?
Methyl Isopropyl Ketone has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted.
Methyl Isopropyl Ketone
Also known as: 2-Acetyl propane, Caswell No. 555A, EINECS 209-264-3, EPA Pesticide Chemical Code 044104, Ketone, isopropyl methyl (+3 more)
INCI: METHYL ISOPROPYL KETONE (ALSO: 3-METHYL-2-BUTANONE)
Methyl Isopropyl Ketone (CAS 563-80-4) is a cosmetic cosmetic ingredient functioning as Solvent - primarily an industrial solvent with limited direct cosmetic. EU Regulation 1223/2009 status: permitted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 563-80-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Methyl Isopropyl Ketone is classified GHS Danger (H225, H332, H336, H303, H305, H315, H320, H333) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Solvent - primarily an industrial solvent with limited direct cosmetic application
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-methylbutan-2-one
InChIKey
SYBYTAAJFKOIEJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not specifically restricted for cosmetic use; more commonly regulated under industrial chemical frameworks
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methyl Isopropyl Ketone.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
FlamFlameCancerHealth haz
Hazard Statements
Highly flammable liquid and vapour May be harmful if swallowed Causes eye irritation May be harmful if swallowed and enters airways
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. The substance may cause effects on the central nervous system. This may result in lowering of consciousness.
Long-term Exposure Effects
May cause skin dryness or cracking
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Flammable
Hazard Class and Category
Flam. Liq. 2
Hazard Statements
- H225 Highly flammable liquid and vapour
Inserted via ATP: CLP00
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6750 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0922
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
A skin and eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for Methyl Isopropyl Ketone.
Known Synonyms
2-Acetyl propane
Caswell No. 555A
EINECS 209-264-3
EPA Pesticide Chemical Code 044104
Ketone, isopropyl methyl
Methyl butanone-2
Methylbutanone
UNII-V8DP6THY5O
Chemical Function
Fragrance
Flavouring and nutrient
Solvent
Regulatory Lists
air; detected; emissions; Europe; Other direct contact consumer goods
detected; Europe; Other direct contact consumer goods
Europe
air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183920
Frequently Asked Questions
Is Methyl Isopropyl Ketone allowed in the EU?
Methyl Isopropyl Ketone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Isopropyl Ketone do in cosmetics?
Methyl Isopropyl Ketone functions as: Solvent - primarily an industrial solvent with limited direct cosmetic application. It is classified as a cosmetic ingredient in our database. CAS number: 563-80-4.
Is Methyl Isopropyl Ketone classified as hazardous under GHS?
Methyl Isopropyl Ketone carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour May be harmful if swallowed Causes eye irritation May be harmful if swallowed and enters airways. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Methyl Isopropyl Ketone used outside cosmetics?
Methyl Isopropyl Ketone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Methyl Isopropyl Ketone have different safety status in cosmetics vs industrial chemicals?
Methyl Isopropyl Ketone is classified GHS Danger (H225, H332, H336, H303, H305, H315, H320, H333) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Methyl Isopropyl Ketone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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