NOAEL Data Cosmetic Ingredient

N'-(2-hydroxyethyl)-4-nitro-o-phenylenediamine (HC Yellow 5)

Also known as: EINECS 260-450-0, N'-(2-Hydroxyethyl)-4-nitro-ortho-phenylenediamine, UNII-I844A312T7

CAS 56932-44-6

N'-(2-hydroxyethyl)-4-nitro-o-phenylenediamine (HC Yellow 5) (CAS 56932-44-6) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for HC Yellow No. 5 →

SOURCE noael studies public
NOAEL studies
4
SOURCE chemical inventory jurisdictions
Regulatory lists
2
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields
Name
N'-(2-hydroxyethyl)-4-nitro-o-phenylenediamine (HC Yellow 5)
CAS Number
56932-44-6
DTXSID
DTXSID4043939
Molecular Formula
C8H11N3O3
InChI Key
OWMQBFHMJVSJSA-UHFFFAOYSA-N
Monoisotopic Mass
197.080041
Synonyms
EINECS 260-450-0N'-(2-Hydroxyethyl)-4-nitro-ortho-phenylenediamineUNII-I844A312T7

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records
ListKeywordSource
banned; Europe; Personal careEuropean CommissionCosIng
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 4 of 4 studies
ValueUnitEndpointRouteSpeciesSource
I844A312T7UNIIFDA UNII substance identifier--openFDA substances
I844A312T7UNIIFDA UNII substance identifier--openFDA substances
I844A312T7UNIIFDA UNII substance identifier--openFDA substances
I844A312T7UNIIFDA UNII substance identifier--openFDA substances

Showing 4 of 4 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for N'-(2-hydroxyethyl)-4-nitro-o-phenylenediamine (HC Yellow 5)?

N'-(2-hydroxyethyl)-4-nitro-o-phenylenediamine (HC Yellow 5) has 4 NOAEL studies in the database. The lowest reported value is I844A312T7 UNII. Source: openFDA substances.

What regulatory lists include N'-(2-hydroxyethyl)-4-nitro-o-phenylenediamine (HC Yellow 5)?

N'-(2-hydroxyethyl)-4-nitro-o-phenylenediamine (HC Yellow 5) appears on 2 regulatory/inventory lists including banned; Europe; Personal care, Europe; Personal care - hair coloring. Source: EPA CPDat.

Is N'-(2-hydroxyethyl)-4-nitro-o-phenylenediamine (HC Yellow 5) used in cosmetics?

Yes, N'-(2-hydroxyethyl)-4-nitro-o-phenylenediamine (HC Yellow 5) is also indexed as a cosmetic ingredient under the name HC Yellow No. 5. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for N'-(2-hydroxyethyl)-4-nitro-o-phenylenediamine (HC Yellow 5) come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does N'-(2-hydroxyethyl)-4-nitro-o-phenylenediamine (HC Yellow 5) have different safety status in cosmetics vs industrial chemicals?

N'-(2-hydroxyethyl)-4-nitro-o-phenylenediamine (HC Yellow 5) is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319, H335).

Is N'-(2-hydroxyethyl)-4-nitro-o-phenylenediamine (HC Yellow 5) used outside industrial chemicals?

N'-(2-hydroxyethyl)-4-nitro-o-phenylenediamine (HC Yellow 5) also appears in cosmetics databases.