NOAEL Data REACH Registered Cosmetic Ingredient

1,1,1-Trichloro-2-methyl-2-propanol

Also known as: 4-01-00-01629, BRN 0878167, Caswell No. 185, Chlorbutanolum, Chlorbutolum (+10 more)

CAS 57-15-8

1,1,1-Trichloro-2-methyl-2-propanol (CAS 57-15-8) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.

View cosmetic safety profile for Chlorobutanol →

SOURCE noael studies public
NOAEL studies
5
SOURCE chemical inventory jurisdictions
Regulatory lists
5
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 21 fields
Name
1,1,1-Trichloro-2-methyl-2-propanol
CAS Number
57-15-8
DTXSID
DTXSID1041217
Molecular Formula
C4H7Cl3O
InChI Key
OSASVXMJTNOKOY-UHFFFAOYSA-N
Monoisotopic Mass
175.956248
Synonyms
4-01-00-01629BRN 0878167Caswell No. 185ChlorbutanolumChlorbutolumChlorobutanol, anhydrousEINECS 200-317-6EPA Pesticide Chemical Code 0175012-Propanol, 2-methyl-1,1,1-trichloro-Trichloro-tert-butanolbeta,beta,beta-Trichloro-tert-butyl alcoholTrichloro-t-butyl alcohol

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Preservative

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records
ListKeywordSource
PesticidesNational Park ServiceCPCat
pharmaceuticalUS International Trade CommissionCPCat
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
Europe; Personal careEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 5 of 5 studies
ValueUnitEndpointRouteSpeciesSource
HM4YQM8WRCUNIIFDA UNII substance identifier--openFDA substances
HM4YQM8WRCUNIIFDA UNII substance identifier--openFDA substances
HM4YQM8WRCUNIIFDA UNII substance identifier--openFDA substances
HM4YQM8WRCUNIIFDA UNII substance identifier--openFDA substances
<10mg/kg bw/dayNOELoralRatToxValDB_HESS

Showing 5 of 5 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredChlorbutanol200-317-6ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
0.5%
Category
Preservative
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHLOROBUTANOL
ChEMBL Phase
2
Adverse Events
0
Bioactivity
2
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 1,1,1-Trichloro-2-methyl-2-propanol?

1,1,1-Trichloro-2-methyl-2-propanol has 5 NOAEL studies in the database. The lowest reported value is HM4YQM8WRC UNII. Source: openFDA substances.

What regulatory lists include 1,1,1-Trichloro-2-methyl-2-propanol?

1,1,1-Trichloro-2-methyl-2-propanol appears on 4 regulatory/inventory lists including Pesticides, pharmaceutical, Canada; pharmaceutical, and 1 more. Source: EPA CPDat.

Is 1,1,1-Trichloro-2-methyl-2-propanol used in cosmetics?

Yes, 1,1,1-Trichloro-2-methyl-2-propanol is also indexed as a cosmetic ingredient under the name Chlorobutanol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,1,1-Trichloro-2-methyl-2-propanol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 1,1,1-Trichloro-2-methyl-2-propanol used outside industrial chemicals?

1,1,1-Trichloro-2-methyl-2-propanol also appears in cosmetics, pharmaceutical databases.