Is Chlorobutanol safe in cosmetics?
Chlorobutanol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
Chlorobutanol
Also known as: 4-01-00-01629, BRN 0878167, Caswell No. 185, Chlorbutanolum, Chlorbutolum (+10 more)
INCI: CHLOROBUTANOL
Chlorobutanol (CAS 57-15-8) is a cosmetic cosmetic ingredient functioning as Preservative. EU Regulation 1223/2009 status: permitted, max 0.5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Function
Preservative
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
1,1,1-trichloro-2-methylpropan-2-ol
InChIKey
OSASVXMJTNOKOY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.5%
US US Status
permitted
US Notes
FDA: permitted in cosmetics and OTC drugs as preservative; USP/NF monograph exists
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Chlorobutanol.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex V — Permitted Preservatives
Max: 0.5%
Contains Chlorobutanol
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: Preservative. Max: 0.5%. Aerosol prohibited
SA Saudi SFDA (V - Preservatives)
Max: 0.005. Contains Chlorobutanol
JPKR Japan/Korea Cosmetics
Japan (Positive (Preservative)): max 0.10
Japan (Restricted): max 0.10%
BRIN Brazil/India Cosmetics
Brazil: Permitted Preservative · max 0,5%
India: Permitted Preservative · max 0.005
Additional Jurisdictional Restrictions (5)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| JP | restricted | 0.10% | All cosmetics |
| IN | permitted_preservative | 0.5 | all cosmetics |
| GCC | banned | - | All cosmetics |
| BR | permitted_preservative | 0.5 | Prohibited in sprayable systems (aerosols/sprays) |
| ASEAN | permitted_preservative | 0.5% | All products |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
A skin and eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Preservative
Regulatory List Membership (2)
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Editorial summary
Preliminary editorial summary for Chlorobutanol — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
preservative
eu_cosing_listed
Known Synonyms
4-01-00-01629
BRN 0878167
Caswell No. 185
Chlorbutanolum
Chlorbutolum
Chlorobutanol, anhydrous
EINECS 200-317-6
EPA Pesticide Chemical Code 017501
2-Propanol, 2-methyl-1,1,1-trichloro-
Trichloro-tert-butanol
beta,beta,beta-Trichloro-tert-butyl alcohol
Trichloro-t-butyl alcohol
Chlorobutanolum
Clorobutanolo
UNII-HM4YQM8WRC
Chemical Function
Preservative
Regulatory Lists
Pesticides
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Europe; Personal care
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CHLOROBUTANOL
ChEMBL ID
CHEMBL1439973
Max Phase
2
Frequently Asked Questions
Is Chlorobutanol allowed in the EU?
Chlorobutanol EU regulatory status: permitted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Chlorobutanol do in cosmetics?
Chlorobutanol functions as: Preservative. It is classified as a cosmetic ingredient in our database. CAS number: 57-15-8.
Is Chlorobutanol used outside cosmetics?
Chlorobutanol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Chlorobutanol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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