What is the NOAEL for D-Fructose?
D-Fructose has 23 NOAEL studies in the database. The lowest reported value is 6YSS42VSEV UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
D-Fructose
Also known as: D-(-)-Levulose, D-(-)-Fructose, Advantose FS 95, D-Arabino-2-Hexulose, arabino-Hexulose (+2 more)
CAS 57-48-7
D-Fructose (CAS 57-48-7) is a chemical substance. Key regulatory status: 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
23
SOURCE
chemical inventory jurisdictions
Regulatory lists
9
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
D-Fructose
CAS Number
57-48-7
DTXSID
DTXSID5023081
Molecular Formula
C6H12O6
InChI Key
BJHIKXHVCXFQLS-UYFOZJQFSA-N
Monoisotopic Mass
180.063388
Synonyms
D-(-)-LevuloseD-(-)-FructoseAdvantose FS 95D-Arabino-2-Hexulosearabino-HexuloseEINECS 200-333-3UNII-6YSS42VSEV
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | May cause mechanical irritation. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
13 records
HumectantFlavouring and nutrientFragranceProcessing aids not otherwise specifiedThickening agentSolvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 23 of 23 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 6YSS42VSEV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6YSS42VSEV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6YSS42VSEV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6YSS42VSEV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| 10000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 16000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 24000 | mg/kg bw/day | NOAEL | oral | swine | COSMOS_DB |
| 29000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 30000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 30500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 33000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 40000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 50000 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 60000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 66200 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 68000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 69000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 77000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 105000 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
Showing 23 of 23 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
FRUCTOSE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include D-Fructose?
D-Fructose appears on 7 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, active_ingredient; Pesticides, and 4 more. Source: EPA CPDat.
Is D-Fructose used in cosmetics?
Yes, D-Fructose is also indexed as a cosmetic ingredient under the name Fructose. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for D-Fructose come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is D-Fructose used outside industrial chemicals?
D-Fructose also appears in cosmetics, pharmaceutical, food safety, cannabis databases.