Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Fructose. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 24000 mg/kg bw/day | oral | swine | Short Term Toxicity | COSMOS_DB |
| NOAEL | 60000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 105000 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 77000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 68000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 68000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 68000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 69000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 40000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 68000 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Fructose is a clean cosmetic ingredient with no restrictions in EU or US, GRAS-affirmed, CIR-safe, and eligible for natural certification programs.
Regulatory Flags
Frequently Asked Questions
Is Fructose safe in cosmetics?
Fructose is a clean cosmetic ingredient with no restrictions in EU or US, GRAS-affirmed, CIR-safe, and eligible for natural certification programs. The EU classifies Fructose as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Fructose allowed in the EU?
Fructose EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Fructose do in cosmetics?
Fructose functions as: Humectant, Skin Conditioning, Flavoring Agent. It is classified as a Cosmetic Ingredient in our database. CAS number: 57-48-7.
What is the Margin of Safety for Fructose?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Fructose?
The NOAEL (No Observed Adverse Effect Level) for Fructose is 24000 mg/kg bw/day based on a Short Term Toxicity study via oral route in swine. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Fructose compliance across multiple jurisdictions:
Related Ingredients
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