Is Fructose safe in cosmetics?
Fructose has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Fructose
Also known as: D-(-)-Levulose, D-(-)-Fructose, Advantose FS 95, D-Arabino-2-Hexulose, arabino-Hexulose (+2 more)
INCI: FRUCTOSE
Fructose (CAS 57-48-7) is a cosmetic cosmetic ingredient functioning as Humectant, Skin Conditioning, Flavoring Agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 57-48-7 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant, Skin Conditioning, Flavoring Agent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(3S,4R,5R)-2-(hydroxymethyl)oxane-2,3,4,5-tetrol
InChIKey
LKDRXBCSQODPBY-VRPWFDPXSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS as direct food additive under 21 CFR 184.1866. CIR concluded safe in present practices of use (2019).
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Fructose.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
May cause mechanical irritation.
Additional Ingredient Properties
6 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "hydration-plumping", "mechanism_of_action": "Humectant, water binding, barrier support", "target_skin_layer": "stratum corneum, epidermis", "collagen_stimulation": "No", "elastin_protection": "No", "wrinkle_reduction_pct": "5-10", "clinical_study_duration_weeks": "8", "sample_size": "30", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "JDD, Int J Cosm…
hair_care
{"hair_function": "moisturizing", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "moisture", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "neutral", "ker…
humectant
{"cas_number": "57-48-7", "ingredient_class": "humectant/sugar_derivative", "molecular_weight_Da": "180.16", "chemical_type": "polysaccharide", "water_binding_mechanism": "hydrogen_bonding/hygroscopic", "water_holding_capacity_g_per_g": "0.6-0.8", "hygroscopicity_at_50_RH": "excellent", "hygroscopicity_at_80_RH": "excellent", "NMF_component": "no", "NMF_percentage_natural": "0", "TEWL_reduction_pc…
pediatric_safety
{"safe_for_newborn_0_6m": "yes", "safe_for_infant_6_12m": "yes", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "10.0", "adult_max_concentration_pct": "10.0", "pediatric_dermal_absorption_factor": "normal", "oral_ingestion_risk": "low", "diaper_area_safe": "yes", "pediatric_allergy_prevalence": "low", "banned_in_chil…
ph_stability
{"optimal_ph_min": "3.0", "optimal_ph_max": "9.0", "stable_ph_min": "3.0", "stable_ph_max": "10.0", "ph_dependent_function": "Simple sugar humectant", "formulation_note": "Natural moisturizer", "source": "Formulation literature"}
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "recommended", "sensitive_skin": "acceptable", "combination_skin": "acceptable", "normal_skin": "recommended", "acne_prone": "acceptable", "rosacea": "acceptable", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "acceptable", "dehydrated": "recommended", "skin_benefit_primary": "humectant", "skin_benefit_secondary": "energizing", "…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1554
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Humectant
Processing aids not otherwise specified
Solvent
Thickening agent
Regulatory List Membership (2)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Fructose.
Regulatory Flags
fda_food_additive
Known Synonyms
D-(-)-Levulose
D-(-)-Fructose
Advantose FS 95
D-Arabino-2-Hexulose
arabino-Hexulose
EINECS 200-333-3
UNII-6YSS42VSEV
Chemical Function
Humectant
Flavouring and nutrient
Fragrance
Processing aids not otherwise specified
Thickening agent
Solvent
Regulatory Lists
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Europe; Pesticides
Canada; pharmaceutical
Canada; pharmaceutical
consumer_product
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
FRUCTOSE
ChEMBL ID
CHEMBL1232863
Max Phase
2
Frequently Asked Questions
Is Fructose allowed in the EU?
Fructose EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Fructose do in cosmetics?
Fructose functions as: Humectant, Skin Conditioning, Flavoring Agent. It is classified as a cosmetic ingredient in our database. CAS number: 57-48-7.
Is Fructose used outside cosmetics?
Fructose also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Fructose compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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