Is Fructose safe in cosmetics?
Fructose has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Fructose
Also known as: D-(-)-Levulose, D-(-)-Fructose, Advantose FS 95, D-Arabino-2-Hexulose, arabino-Hexulose (+2 more)
INCI: FRUCTOSE
Fructose (CAS 57-48-7) is a cosmetic cosmetic ingredient functioning as Humectant, Skin Conditioning, Flavoring Agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
Humectant, Skin Conditioning, Flavoring Agent
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(3S,4R,5R)-2-(hydroxymethyl)oxane-2,3,4,5-tetrol
InChIKey
LKDRXBCSQODPBY-VRPWFDPXSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS as direct food additive under 21 CFR 184.1866. CIR concluded safe in present practices of use (2019).
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Fructose.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
May cause mechanical irritation.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1554
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Humectant
Processing aids not otherwise specified
Solvent
Thickening agent
Regulatory List Membership (2)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for Fructose — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fda_food_additive
Known Synonyms
D-(-)-Levulose
D-(-)-Fructose
Advantose FS 95
D-Arabino-2-Hexulose
arabino-Hexulose
EINECS 200-333-3
UNII-6YSS42VSEV
Chemical Function
Humectant
Flavouring and nutrient
Fragrance
Processing aids not otherwise specified
Thickening agent
Solvent
Regulatory Lists
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Europe; Pesticides
Canada; pharmaceutical
Canada; pharmaceutical
consumer_product
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
FRUCTOSE
ChEMBL ID
CHEMBL1232863
Max Phase
2
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Fructose
Food Category
sweetener_natural
Frequently Asked Questions
Is Fructose allowed in the EU?
Fructose EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Fructose do in cosmetics?
Fructose functions as: Humectant, Skin Conditioning, Flavoring Agent. It is classified as a cosmetic ingredient in our database. CAS number: 57-48-7.
Is Fructose used outside cosmetics?
Fructose also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Fructose compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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