NOAEL Data Prop 65 Cosmetic Ingredient

17alpha-Ethinylestradiol

Also known as: EE, EE2, Ethinyl estradiol, 19-​Norpregna-​1,​3,​5(10)​-​trien-​20-​yne-​3,​17-​diol, (17α)​-, 19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17.alpha.)- (+15 more)

CAS 57-63-6

17alpha-Ethinylestradiol (CAS 57-63-6) is a chemical substance; key hazard signal: cancer. Key regulatory status: California Proposition 65, 15 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, CA Prop 65.

View cosmetic safety profile for Ethinylestradiol →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
15
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields
Name
17alpha-Ethinylestradiol
CAS Number
57-63-6
DTXSID
DTXSID5020576
Molecular Formula
C20H24O2
InChI Key
BFPYWIDHMRZLRN-SLHNCBLASA-N
Monoisotopic Mass
296.17763
Synonyms
EEEE2Ethinyl estradiol19-​Norpregna-​1,​3,​5(10)​-​trien-​20-​yne-​3,​17-​diol, (17α)​-19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17.alpha.)-19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17alpha)-AethinyloestradiolumAmenoroneBRN 24199753,17beta-Dihydroxy-17alpha-ethynyl-1,3,5(10)-estratriene3,17-beta-Dihydroxy-17-alpha-ethynyl-1,3,5(10)-estratriene3,17beta-Dihydroxy-17alpha-ethynyl-1,3,5(10)-oestratriene

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records
ChemicalToxicity TypeCancerDevelopmentalListed
-cancerYesNo-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records
Softener and conditioner

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 15 records
ListKeywordSource
detected; drinking_water; MN Chemical ScreeningEPA & USGSState of Minnesota
OEHHA Proposition 65 (1/2023)California Office of Environmental Health Hazard AssessmentOEHHA Proposition 65 List
Canada; Personal care; Substances in PCP - Canada (4/2014)Government of CanadaCPCat
pharmaceuticalUS International Trade CommissionCPCat
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
OEHHA Proposition 65 (3/2019)STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCYOEHHA Proposition 65 List
Canada; pharmaceuticalDrugBankDrugBank
OEHHA Proposition 65 (1/2023)California Office of Environmental Health Hazard AssessmentOEHHA Proposition 65 List
active_ingredient; AustraliaAustralian Pesticides and Veterinary Medicines AuthorityCPCat
detected; MN Chemical Screening; wastewaterMinnesota Pollution Control AgencyState of Minnesota
detected; MN Chemical Screening; surface_waterMinnesota Pollution Control AgencyState of Minnesota
detected; MN Chemical Screening; wastewaterMinnesota Pollution Control AgencyState of Minnesota
detected; drinking_water; MN Chemical ScreeningEPAState of Minnesota
detected; drinking_water; MN Chemical ScreeningEPAState of Minnesota
detected; drinking_water; MN Chemical ScreeningEPAState of Minnesota

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
0.00101416222081225uMAC50--NTP_ICE_endocrine
1.005653731uMAC50--NTP_ICE_endocrine
50nMAC50/EC50/IC50--NTP_ICE_endocrine
180nMAC50/EC50/IC50--NTP_ICE_endocrine
700nMAC50/EC50/IC50--NTP_ICE_endocrine
6170nMAC50/EC50/IC50--NTP_ICE_endocrine
8000nMAC50/EC50/IC50--NTP_ICE_endocrine
0.000524643424922395uMACC--NTP_ICE_endocrine
0.577961914uMACC--NTP_ICE_endocrine
=0.000042mg/kg bw/dayBMDL (10)oralRatToxValDB_MN_MDH_HHBW
SQEcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
SQEcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
SQEcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
SQEcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
-uL/min/10^6 cellsClint-HumanNTP_ICE_adme_parameters
0.00731nMEC50--NTP_ICE_endocrine
423D2T571UUNIIFDA UNII substance identifier--openFDA substances
423D2T571UUNIIFDA UNII substance identifier--openFDA substances
423D2T571UUNIIFDA UNII substance identifier--openFDA substances
423D2T571UUNIIFDA UNII substance identifier--openFDA substances
0.014fractionFu-HumanNTP_ICE_adme_parameters
<300nMIC25--NTP_ICE_endocrine
=0.000005mg/dayLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=0.00001mg/kg bw/dayLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=0.00003mg/dayLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=0.00005mg/dayLELoralMouseToxValDB_Uterotrophic_Hershberger_DB
=0.00007mg/kg bw/dayLELoralRatToxValDB_Uterotrophic_Hershberger_DB
=0.0001mg/kg bw/dayLELoralRatToxValDB_Uterotrophic_Hershberger_DB
=0.0001ppmLELoralMouseToxValDB_Uterotrophic_Hershberger_DB
=0.0001mg/dayLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=0.00012mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=0.00012mg/kg bw/dayLELoralrat (sprague dawley; Sprague Dawley)ToxRefDB_ToxRefDB_v3_pod.csv
=0.00015mg/kg bw/dayLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=0.0002mg/kg bw/dayLELoralRatToxValDB_Uterotrophic_Hershberger_DB
=0.0003mgLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=0.0003mg/kg bw/dayLELoralRatToxValDB_Uterotrophic_Hershberger_DB
=0.000312mg/dayLELoralRatToxValDB_Uterotrophic_Hershberger_DB
=0.000342mg/kg bw/dayLELoralRatToxValDB_Uterotrophic_Hershberger_DB
=0.0006mg/kg bw/dayLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=0.0007mg/kg bw/dayLELoralRatToxValDB_Uterotrophic_Hershberger_DB
=0.001fractional dose of pillLELoralMouseToxValDB_Uterotrophic_Hershberger_DB
=0.001mg/kg bw/dayLELoralRatToxValDB_Uterotrophic_Hershberger_DB
=0.0018mg/kg bw/dayLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=0.002mg/kg bw/dayLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=0.0021mg/kg bw/dayLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=0.003mg/kg bw/dayLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=0.006mg/kg bw/dayLELoralRatToxValDB_Uterotrophic_Hershberger_DB
=0.01mg/kg bw/dayLELoralRatToxValDB_Uterotrophic_Hershberger_DB
=0.03mg/kg bw/dayLELoralRatToxValDB_Uterotrophic_Hershberger_DB
=0.0337mg/kg bw/dayLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB

Showing 50 of 100 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ETHINYL ESTRADIOL
ChEMBL Phase
4
Adverse Events
2055
Bioactivity
31
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 17alpha-Ethinylestradiol?

17alpha-Ethinylestradiol has 100 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include 17alpha-Ethinylestradiol?

17alpha-Ethinylestradiol appears on 10 regulatory/inventory lists including detected; drinking_water; MN Chemical Screening, OEHHA Proposition 65 (1/2023), Canada; Personal care; Substances in PCP - Canada (4/2014), and 7 more. Source: EPA CPDat.

Is 17alpha-Ethinylestradiol on the California Proposition 65 list?

Yes, 17alpha-Ethinylestradiol is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.

Is 17alpha-Ethinylestradiol used in cosmetics?

Yes, 17alpha-Ethinylestradiol is also indexed as a cosmetic ingredient under the name Ethinylestradiol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 17alpha-Ethinylestradiol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, California Proposition 65, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 17alpha-Ethinylestradiol have different safety status in cosmetics vs industrial chemicals?

17alpha-Ethinylestradiol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H350, H360, H372, H410).

Is 17alpha-Ethinylestradiol used outside industrial chemicals?

17alpha-Ethinylestradiol also appears in cosmetics, pharmaceutical databases.