What is the NOAEL for Progesterone?
Progesterone has 100 NOAEL studies in the database. The lowest reported value is 0.0017 nM. Source: NTP_ICE_endocrine.
NOAEL Data
Prop 65
REACH Registered
Cosmetic Ingredient
Progesterone
Also known as: Pregn-4-ene-3,20-dione, EINECS 200-350-6, 17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione, 6alpha-Methylpregn-4-en-17alpha-ol-3,20-dione, NSC-9704 (+14 more)
CAS 57-83-0
Progesterone (CAS 57-83-0) is a chemical substance; key hazard signal: cancer. Key regulatory status: California Proposition 65, REACH registered, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, CA Prop 65.
Cross-Vertical Regulatory Divergence
Progesterone is prohibited in EU cosmetics but has active industrial GHS classifications (H350, H351, H360, H360FD, H361, H362, H410).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
11
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Progesterone
CAS Number
57-83-0
DTXSID
DTXSID3022370
Molecular Formula
C21H30O2
InChI Key
RJKFOVLPORLFTN-LEKSSAKUSA-N
Monoisotopic Mass
314.22458
Synonyms
Pregn-4-ene-3,20-dioneEINECS 200-350-617alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione6alpha-Methylpregn-4-en-17alpha-ol-3,20-dioneNSC-97044-Pregnene-3,20-dionePregn-4-ene-3,20-dione, 17alpha-hydroxy-6alpha-methyl-ProjestajectUNII-4G7DS2Q64Y(1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-6-en-5-one(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one(8S,9S,10R,13S,14S,17S)-17-ethanoyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
11 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| Canada; pharmaceutical | DrugBank | DrugBank |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.144967638469244 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 4.11784300763846 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 0.0017 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.279 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 1 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 5.71 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 7.413 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 9.59 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 10 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 14.13 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 20 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 25.5 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 28.11 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 30.8 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 33.88 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 40 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 41.69 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 44 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 46 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 61.66 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 88.2 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| >100 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 107.2 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 108 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 138 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 141 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 177.8 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 180 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 208.9 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 253 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 293 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 297 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| >320 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 401 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 467 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 500 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 560 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 601 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 602.6 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 674 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 741.3 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 900 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 990 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| >1000 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 1430 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 2335 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 2400 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 4160 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 4880 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 5000 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Progesterone | 200-350-6 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PROGESTERONE
ChEMBL Phase
4
Adverse Events
4968
Bioactivity
36
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Progesterone?
Progesterone appears on 8 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), pharmaceutical, active_ingredient; animal_products; Europe; pharmaceutical; residue, and 5 more. Source: EPA CPDat.
Is Progesterone on the California Proposition 65 list?
Yes, Progesterone is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Is Progesterone used in cosmetics?
Yes, Progesterone is also indexed as a cosmetic ingredient under the name Progesterone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Progesterone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, California Proposition 65, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Progesterone have different safety status in cosmetics vs industrial chemicals?
Progesterone is prohibited in EU cosmetics but has active industrial GHS classifications (H350, H351, H360, H360FD, H361, H362, H410).
Is Progesterone used outside industrial chemicals?
Progesterone also appears in cosmetics, pharmaceutical, cannabis databases.