Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Progesterone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 0.5 mg/kg bw/day | 2400 | monkey | other | REACH |
Expert Verdict
🛑 BANNED. Endocrine disruptor; CMR classified (reproductive toxicant). Cannot be used in any cosmetic formulation in the EU or US. High dermal absorption makes even trace contamination a compliance risk.
Regulatory Flags
Frequently Asked Questions
Is Progesterone safe in cosmetics?
🛑 BANNED. Endocrine disruptor; CMR classified (reproductive toxicant). Cannot be used in any cosmetic formulation in the EU or US. High dermal absorption makes even trace contamination a compliance risk. The EU classifies Progesterone as "prohibited". Safety rating: POOR. 2 toxicological study endpoint(s) are available in our database.
Is Progesterone allowed in the EU?
Progesterone EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Progesterone do in cosmetics?
Progesterone functions as: Hormonal substance (skin conditioning — historical use). It is classified as a cosmetic ingredient in our database. CAS number: 57-83-0.
What is the Margin of Safety for Progesterone?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Progesterone?
The NOAEL (No Observed Adverse Effect Level) for Progesterone is 100 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
Check Progesterone compliance across multiple jurisdictions:
Related Ingredients
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