Also known as: Propylene glycol mono-t-butyl ether, BRN 1734501, Propylene glycol t-butyl ether, UNII-03077MV85B, Propylene glycol mono-t-buthyl ether
CAS 57018-52-7
1-tert-Butoxy-2-propanol (CAS 57018-52-7) is a chemical substance with GHS signal word Danger; key hazard signal: H226; H318. Key regulatory status: California Proposition 65, REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, IARC, ECHA REACH, CA Prop 65, ILO ICSC.
View cosmetic safety profile for Propylene Glycol t-Butyl Ether →
1-tert-Butoxy-2-propanol is classified GHS Danger (H226, H318) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 2017 | 88, 119 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 3; Eye Dam. 1 | H226; H318 | GHS02; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Flammable liquid and vapour Causes serious eye irritation |
| Short-term Effects | The substance is severely irritating to the eyes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 03077MV85B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 03077MV85B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 03077MV85B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 03077MV85B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =3771 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 6488.49079754601 | mg/m3/day | POLY-3 lowest dose | Inhalation | Mouse | NTP_ICE_cancer |
| - | % | Positive reaction | Dermal | Human | NTP_ICE_skin_irritation |
| 1200 | ppm | Top dose | Inhalation | Rat | NTP_ICE_cancer |
Showing 14 of 14 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1-tert-butoxypropan-2-ol | 406-180-0 | ECHA overview → |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
1-tert-Butoxy-2-propanol (CAS 57018-52-7) is classified under EU CLP Annex VI as Flam. Liq. 3; Eye Dam. 1 with signal word Danger. Hazard statements: H226; H318. Source: EU CLP Annex VI (ECHA).
1-tert-Butoxy-2-propanol has 14 NOAEL studies in the database. The lowest reported value is cancer listing type. Source: California Proposition 65.
1-tert-Butoxy-2-propanol appears on 3 regulatory/inventory lists including detected; Europe; Specialty occupational products, OEHHA Proposition 65 (3/2019), OEHHA Proposition 65 (1/2023). Source: EPA CPDat.
1-tert-Butoxy-2-propanol is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2017). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, 1-tert-Butoxy-2-propanol is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Yes, 1-tert-Butoxy-2-propanol is also indexed as a cosmetic ingredient under the name Propylene Glycol t-Butyl Ether. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
1-tert-Butoxy-2-propanol is classified GHS Danger (H226, H318) in the chemicals database but is allowed in EU cosmetics.
1-tert-Butoxy-2-propanol also appears in cosmetics, pharmaceutical databases.