Moderate Cosmetic Ingredient GHS Classified

Propylene Glycol t-Butyl Ether

INCI: PROPYLENE GLYCOL T-BUTYL ETHER

CAS Number
57018-52-7
Function
Solvent, Fragrance
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR: Assessed within butyl polyoxyalkylene ethers group — safe when formulated to be non-irritating

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
WARNING
Pictograms
flam;flame; excl mark;warn
Hazard Statements
Flammable liquid and vapour Causes serious eye irritation
Short-term Exposure Effects
The substance is severely irritating to the eyes.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.

Expert Verdict

⚠ Severely irritating to rabbit eyes; slightly–moderately irritating to abraded skin; systemic dermal exposure possible; NTP nominated for further toxicological study due to data gaps

⚠️
Concern Level: High

Regulatory Flags

fragrance-component prop65

Frequently Asked Questions

Is Propylene Glycol t-Butyl Ether safe in cosmetics?

⚠ Severely irritating to rabbit eyes; slightly–moderately irritating to abraded skin; systemic dermal exposure possible; NTP nominated for further toxicological study due to data gaps The EU classifies Propylene Glycol t-Butyl Ether as "permitted". Safety rating: MODERATE.

Is Propylene Glycol t-Butyl Ether allowed in the EU?

Propylene Glycol t-Butyl Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Propylene Glycol t-Butyl Ether do in cosmetics?

Propylene Glycol t-Butyl Ether functions as: Solvent, Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 57018-52-7.

What is the Margin of Safety for Propylene Glycol t-Butyl Ether?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Is Propylene Glycol t-Butyl Ether classified as hazardous under GHS?

Propylene Glycol t-Butyl Ether carries a GHS signal word of "WARNING". Hazard statements: Flammable liquid and vapour Causes serious eye irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

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