What is the NOAEL for Isopulegyl acetate?
Isopulegyl acetate has 10 NOAEL studies in the database. The lowest reported value is R3C4VQ5WQM UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Isopulegyl acetate
Also known as: Cyclohexanol, 5-methyl-2-(1-methylethenyl)-, 1-acetate, (1R,2S,5R)-, Cyclohexanol, 5-methyl-2-(1-methylethenyl)-, acetate, (1R,2S,5R)-
CAS 57576-09-7
Isopulegyl acetate (CAS 57576-09-7) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
Isopulegyl acetate is classified GHS Danger (H351, H372) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
8 fields
Name
Isopulegyl acetate
CAS Number
57576-09-7
DTXSID
DTXSID60904398
Molecular Formula
C12H20O2
InChI Key
HLHIVJRLODSUCI-ADEWGFFLSA-N
Monoisotopic Mass
196.14633
Synonyms
Cyclohexanol, 5-methyl-2-(1-methylethenyl)-, 1-acetate, (1R,2S,5R)-Cyclohexanol, 5-methyl-2-(1-methylethenyl)-, acetate, (1R,2S,5R)-
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| R3C4VQ5WQM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R3C4VQ5WQM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R3C4VQ5WQM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R3C4VQ5WQM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5184 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =38 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =38 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =38 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 10 of 10 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3120645
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Isopulegyl acetate?
Isopulegyl acetate appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, consumer_product. Source: EPA CPDat.
Is Isopulegyl acetate used in cosmetics?
Yes, Isopulegyl acetate is also indexed as a cosmetic ingredient under the name Isopulegyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Isopulegyl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Isopulegyl acetate have different safety status in cosmetics vs industrial chemicals?
Isopulegyl acetate is classified GHS Danger (H351, H372) in the chemicals database but is restricted in EU cosmetics.
Is Isopulegyl acetate used outside industrial chemicals?
Isopulegyl acetate also appears in cosmetics, pharmaceutical, cannabis databases.