NOAEL Data REACH Registered Cosmetic Ingredient

Docusate sodium

Also known as: Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt, Bis(2-ethylhexyl) sodium sulfosuccinate, Butanedioic acid, sulfo-, 1,4-dioctyl ester, sodium salt, Bis(ethylhexyl) ester of sodium sulfosuccinic acid, Bis(2-ethylhexyl)sodium sulfosuccinate (+15 more)

CAS 577-11-7

Docusate sodium (CAS 577-11-7) is a chemical substance. Key regulatory status: REACH registered, 16 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Diethylhexyl Sodium Sulfosuccinate →

SOURCE NOAEL studies
NOAEL studies
39
SOURCE Chemical inventory jurisdictions
Regulatory lists
16
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 24 fields
Name
Docusate sodium
CAS Number
577-11-7
Molecular Formula
C20H38O7S.Na
InChI Key
APSBXTVYXVQYAB-UHFFFAOYSA-M
Synonyms
Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium saltBis(2-ethylhexyl) sodium sulfosuccinateButanedioic acid, sulfo-, 1,4-dioctyl ester, sodium saltBis(ethylhexyl) ester of sodium sulfosuccinic acidBis(2-ethylhexyl)sodium sulfosuccinateClestolDioctyl ester of sodium sulfosuccinateDioctyl ester of sodium sulfosuccinic acidEINECS 209-406-42-Ethylhexyl sulfosuccinate sodiumLaxinate 100Manoxal OT

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 41 records
Surfactant (surface active agent)Solubility enhancerEmulsifierCleaning agentPigmentFragranceAnti-adhesive/cohesiveWetting agent (non-aqueous)Dispersing agentAnti-static agentFlow promoter

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 16 records
ListKeywordSource
IFRA TransparencyIFRAIFRA
Europe; Specialty occupational productsDanish Environmental Protection AgencyDanish EPA
Europe; Specialty occupational productsDanish Environmental Protection AgencyDanish EPA
pharmaceuticalUS International Trade CommissionCPCat
Europe; plastic_additiveEuropean Chemicals AgencyEuropean Chemicals Agency (ECHA)
Arts and crafts/Office supplies - fabric treatment and dye; detectedDanish Environmental Protection AgencyDanish EPA
inert_ingredient; PesticidesEPACPCat
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 39 of 39 studies
ValueUnitEndpointRouteSpeciesSource
19.36uMAC50--NTP ICE endocrine
19.09uMACC--NTP ICE endocrine
49.8uL/min/10^6 cellsClint-HumanNTP ICE adme parameters
=1889mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
57unitlessDraize rabbit irritation scoreOcularRabbitNTP ICE eye irritation
F05Q2T2JA0UNIIFDA UNII substance identifier--openFDA substances
1unitlessGHS ClassificationOcularRabbitNTP ICE eye irritation
0.24%/secIntensityOcular-NTP ICE eye irritation
=0.5%LOELoralRatToxValDB ECOTOX
=260mg/kg bw/dayLOELoralRatToxValDB ECOTOX
=1500mg/kg bw/dayLOELoralRatToxValDB ECOTOX
=1.000e+4ppmLOELoralRatToxValDB ECOTOX
0sLag timeOcular-NTP ICE eye irritation
0unitlessModel Score--NTP ICE endocrine
0.124unitlessModel Score--NTP ICE endocrine
=0.5%NOAELoralratCIR Safety Assessment
=1%NOAELoralratCIR Safety Assessment
30mg/kg bw/dayNOAELoraldogCOSMOS DB
>30mg/kg bwNOAELinhalationrabbitCIR Safety Assessment
=50%NOAELoralratCIR Safety Assessment
63mg/kg bw/dayNOAELoralratCOSMOS DB
=400mg/kg bwNOAELoralratCIR Safety Assessment
500mg/kg bw/dayNOAELoralratCOSMOS DB
574mg/kg bw/dayNOAELoralratCOSMOS DB
650mg/kg bw/dayNOAELoralhorseCOSMOS DB
700mg/kg bw/dayNOAELoralguinea pigCOSMOS DB
870mg/kg bw/dayNOAELoralratCOSMOS DB
1000mg/kg bw/dayNOAELoralratCOSMOS DB
1988mg/kg bw/dayNOAELoralratCOSMOS DB
=0.078mg/kg bw/dayNOELoralRatToxValDB ECOTOX
=0.1%NOELoralRatToxValDB ECOTOX
=0.5%NOELoralRatToxValDB ECOTOX
=1%NOELoralRatToxValDB ECOTOX
35%Plateau levelOcular-NTP ICE eye irritation
1%developmental toxicityoralratRegulatory source
50%developmental toxicityoralratRegulatory source
400mg/kg bwdevelopmental toxicityoralratRegulatory source
>30mg/kg bwinhalation toxicityinhalationrabbitRegulatory source
0.5%oral toxicityoralratRegulatory source

Showing 39 of 39 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredDocusate sodium209-406-4ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed DOCUSATE SODIUM
ChEMBL Phase
3
Adverse Events
1696
Bioactivity
1
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

E480 — ADI: 0-0.1 mg/kg bw mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Docusate sodium?

Docusate sodium has 39 NOAEL studies in the database. The lowest reported value is 0 s via Ocular. Source: NTP ICE eye irritation.

What regulatory lists include Docusate sodium?

Docusate sodium appears on 7 regulatory/inventory lists including IFRA Transparency, Europe; Specialty occupational products, pharmaceutical, and 4 more. Source: EPA CPDat.

Is Docusate sodium used in cosmetics?

Yes, Docusate sodium is also indexed as a cosmetic ingredient under the name Diethylhexyl Sodium Sulfosuccinate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Docusate sodium come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Docusate sodium have different safety status in cosmetics vs industrial chemicals?

Docusate sodium is classified GHS Danger (H302, H315, H318, H319, H361, H362, H402, H412) in the chemicals database but is allowed in EU cosmetics.

Is Docusate sodium used outside industrial chemicals?

Docusate sodium also appears in cosmetics, pharmaceutical, food safety, cannabis databases.