Diethylhexyl Sodium Sulfosuccinate
INCI: DIETHYLHEXYL SODIUM SULFOSUCCINATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Diethylhexyl Sodium Sulfosuccinate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 650 mg/kg bw/day | oral | horse | Special Toxicology Study | COSMOS_DB |
| NOAEL | 700 mg/kg bw/day | oral | guinea pig | Special Toxicology Study | COSMOS_DB |
| NOAEL | 30 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1988 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 63 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 870 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 574 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| dose_tested | 30 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
Expert Verdict
Diethylhexyl Sodium Sulfosuccinate is assessed safe by CIR with negligible dermal absorption, non-sensitizing status across multiple HRIPTs, and very low acute dermal toxicity. Key formulation caution is its penetration-enhancing activity.
Regulatory Flags
Frequently Asked Questions
Is Diethylhexyl Sodium Sulfosuccinate safe in cosmetics?
Diethylhexyl Sodium Sulfosuccinate is assessed safe by CIR with negligible dermal absorption, non-sensitizing status across multiple HRIPTs, and very low acute dermal toxicity. Key formulation caution is its penetration-enhancing activity. The EU classifies Diethylhexyl Sodium Sulfosuccinate as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Diethylhexyl Sodium Sulfosuccinate allowed in the EU?
Diethylhexyl Sodium Sulfosuccinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethylhexyl Sodium Sulfosuccinate do in cosmetics?
Diethylhexyl Sodium Sulfosuccinate functions as: Surfactant, Cleansing, Emulsifying, Wetting Agent, Penetration Enhancer. It is classified as a cosmetic ingredient in our database. CAS number: 577-11-7.
What is the Margin of Safety for Diethylhexyl Sodium Sulfosuccinate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diethylhexyl Sodium Sulfosuccinate?
The NOAEL (No Observed Adverse Effect Level) for Diethylhexyl Sodium Sulfosuccinate is 650 mg/kg bw/day based on a Special Toxicology Study study via oral route in horse. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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