Is Diethylhexyl Sodium Sulfosuccinate safe in cosmetics?
Diethylhexyl Sodium Sulfosuccinate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Diethylhexyl Sodium Sulfosuccinate
Also known as: Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt, Bis(2-ethylhexyl) sodium sulfosuccinate, Butanedioic acid, sulfo-, 1,4-dioctyl ester, sodium salt, Bis(ethylhexyl) ester of sodium sulfosuccinic acid, Bis(2-ethylhexyl)sodium sulfosuccinate (+15 more)
INCI: DIETHYLHEXYL SODIUM SULFOSUCCINATE
Diethylhexyl Sodium Sulfosuccinate (CAS 577-11-7) is a cosmetic cosmetic ingredient functioning as Surfactant, Cleansing, Emulsifying, Wetting Agent, Penetration Enhancer. NOAEL 0.078 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 577-11-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Diethylhexyl Sodium Sulfosuccinate is classified GHS Danger (H302, H315, H318, H319, H361, H362, H402, H412) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Surfactant, Cleansing, Emulsifying, Wetting Agent, Penetration Enhancer
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
sodium 1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate
InChIKey
APSBXTVYXVQYAB-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA cosmetic restrictions. GRAS for OTC laxative use. Approved food additive under 21 CFR 172.520.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diethylhexyl Sodium Sulfosuccinate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Diethylhexyl Sodium Sulfosuccinate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =400 mg/kg bw | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =400 mg/kg bw | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =400 mg/kg bw | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =400 mg/kg bw | oral | rat | developmental toxicity | CIR_vision_codex |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diethylhexyl Sodium Sulfosuccinate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
DSS | 2025 | 0-0.1 mg/kg bw | Considered for exposure only. | TRS 1058-JECFA 100/24 | FAS 91-JECFA 100/73
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-adhesive/cohesive
Anti-static agent
Cleaning agent
Dispersing agent
Emulsifier
Flow promoter
Fragrance
Pigment
Solubility enhancer
Surfactant (surface active agent)
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Diethylhexyl Sodium Sulfosuccinate.
Regulatory Flags
cir-safe
no-sccs-opinion
penetration-enhancer-caution
cumulative-irritant-potential
low-dermal-absorption
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Diethylhexyl Sodium Sulfosuccinate by CAS number or substance name.
Studies
4
Lowest NOAEL
400 mg/kg bw
Highest NOAEL
400 mg/kg bw
CIR_vision_codex
Known Synonyms
Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt
Bis(2-ethylhexyl) sodium sulfosuccinate
Butanedioic acid, sulfo-, 1,4-dioctyl ester, sodium salt
Bis(ethylhexyl) ester of sodium sulfosuccinic acid
Bis(2-ethylhexyl)sodium sulfosuccinate
Clestol
Dioctyl ester of sodium sulfosuccinate
Dioctyl ester of sodium sulfosuccinic acid
EINECS 209-406-4
2-Ethylhexyl sulfosuccinate sodium
Laxinate 100
Manoxal OT
Monawet MD 70E
Monawet MO-70
Monawet MO-84 R2W
Monawet MO-70 RP
Monoxol OT
Natrii dioctylsulfosuccinas
Nekal WT-27
Requtol
Chemical Function
Surfactant (surface active agent)
Solubility enhancer
Emulsifier
Cleaning agent
Pigment
Fragrance
Anti-adhesive/cohesive
Wetting agent (non-aqueous)
Regulatory Lists
IFRA Transparency
Europe; Specialty occupational products
Europe; Specialty occupational products
pharmaceutical
Europe; plastic_additive
Arts and crafts/Office supplies - fabric treatment and dye; detected
inert_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DOCUSATE SODIUM
ChEMBL ID
CHEMBL1905872
Max Phase
3
Adverse Event Associations
1696
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Dioctyl sodium sulfosuccinate
E Number
E480
ADI
0-0.1 mg/kg bw mg/kg bw
Food Category
emulsifier
Frequently Asked Questions
Is Diethylhexyl Sodium Sulfosuccinate allowed in the EU?
Diethylhexyl Sodium Sulfosuccinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethylhexyl Sodium Sulfosuccinate do in cosmetics?
Diethylhexyl Sodium Sulfosuccinate functions as: Surfactant, Cleansing, Emulsifying, Wetting Agent, Penetration Enhancer. It is classified as a cosmetic ingredient in our database. CAS number: 577-11-7.
What is the NOAEL for Diethylhexyl Sodium Sulfosuccinate?
The NOAEL (No Observed Adverse Effect Level) for Diethylhexyl Sodium Sulfosuccinate is =400 mg/kg bw based on a developmental toxicity study via oral route in rat. A total of 4 study endpoints are available. Source: CIR_vision_codex.
Is Diethylhexyl Sodium Sulfosuccinate used outside cosmetics?
Diethylhexyl Sodium Sulfosuccinate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Diethylhexyl Sodium Sulfosuccinate have different safety status in cosmetics vs industrial chemicals?
Diethylhexyl Sodium Sulfosuccinate is classified GHS Danger (H302, H315, H318, H319, H361, H362, H402, H412) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Diethylhexyl Sodium Sulfosuccinate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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