What is the NOAEL for D-alpha-Tocopheryl acetate?
D-alpha-Tocopheryl acetate has 15 NOAEL studies in the database. The lowest reported value is A7E6112E4N UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
D-alpha-Tocopheryl acetate
Also known as: EC No.: 200-405-4, Alfacol, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (2R-(2*(4R*,8R*)))-, Contopheron, 6-Cromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)- (+15 more)
CAS 58-95-7
D-alpha-Tocopheryl acetate (CAS 58-95-7) is a chemical substance. Key regulatory status: 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
NOAEL studies
NOAEL studies
15
SOURCE
Chemical inventory jurisdictions
Regulatory lists
11
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
D-alpha-Tocopheryl acetate
CAS Number
58-95-7
Molecular Formula
C31H52O3
InChI Key
ZAKOWWREFLAJOT-CEFNRUSXSA-N
Monoisotopic Mass
472.391646
Synonyms
EC No.: 200-405-4Alfacol2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (2R-(2*(4R*,8R*)))-Contopheron6-Cromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl acetate, (2R-(2*(4R*,8R*)))-EcofrolEINECS 200-405-4Ephynal acetateEpsilan-ME-Ferol2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-cromanyl acetate, (+)-
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
PreservativeAntioxidantSoftener and conditionerHumectantDeodorizerFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
11 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| A7E6112E4N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5.5 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS DB |
| 6.6 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS DB |
| 47 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 83 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 125 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =540 | mg/day | NOAEL | oral | Human | EFSA |
| =540 | mg/day | NOAEL | - | Human | EFSA |
| 833 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1600 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| =2000 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 4000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =35.71 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB ECOTOX |
Showing 15 of 15 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL1047
ChEMBL Phase
Not listed
Adverse Events
1660
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include D-alpha-Tocopheryl acetate?
D-alpha-Tocopheryl acetate appears on 8 regulatory/inventory lists including IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Canada; pharmaceutical, and 5 more. Source: EPA CPDat.
Is D-alpha-Tocopheryl acetate used in cosmetics?
Yes, D-alpha-Tocopheryl acetate is also indexed as a cosmetic ingredient under the name Tocopheryl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for D-alpha-Tocopheryl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is D-alpha-Tocopheryl acetate used outside industrial chemicals?
D-alpha-Tocopheryl acetate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.