Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Tocopheryl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 4000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5.5 mg/kg bw/day | oral | rabbit | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | hamster | Developmental | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 125 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 47 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Sensitization Profile
Contact sensitization data for Tocopheryl Acetate based on clinical patch test studies and IFRA standards.
Source: IVDK; ESSCA; NACDG
Expert Verdict
Preferred form of vitamin E in cosmetic formulations due to superior oxidative stability. Ester cleavage by skin esterases is incomplete, reducing bioactivity compared to free tocopherol. Recommended at 0.05–0.5% for skin conditioning and antioxidant benefit. Safe for all cosmetic categories. CIR confirmed safety. Synergistic with vitamin C and ferulic acid for antioxidant networks.
Regulatory Flags
Frequently Asked Questions
Is Tocopheryl Acetate safe in cosmetics?
Preferred form of vitamin E in cosmetic formulations due to superior oxidative stability. Ester cleavage by skin esterases is incomplete, reducing bioactivity compared to free tocopherol. Recommended at 0.05–0.5% for skin conditioning and antioxidant benefit. Safe for all cosmetic categories. CIR confirmed safety. Synergistic with vitamin C and ferulic acid for antioxidant networks. The EU classifies Tocopheryl Acetate as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Tocopheryl Acetate allowed in the EU?
Tocopheryl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tocopheryl Acetate do in cosmetics?
Tocopheryl Acetate functions as: Antioxidant; stable ester form of vitamin E; skin-conditioning agent; requires hydrolysis by skin esterases to release active alpha-tocopherol. It is classified as a Antioxidant in our database. CAS number: 58-95-7.
What is the Margin of Safety for Tocopheryl Acetate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Tocopheryl Acetate?
The NOAEL (No Observed Adverse Effect Level) for Tocopheryl Acetate is 500 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Tocopheryl Acetate compliance across multiple jurisdictions:
Related Ingredients
Is Tocopheryl Acetate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Tocopheryl Acetate in your formulation.