Is Tocopheryl Acetate safe in cosmetics?
Tocopheryl Acetate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 8 toxicological study endpoint(s) are available in our database.
Tocopheryl Acetate
Also known as: EC No.: 200-405-4, Alfacol, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (2R-(2*(4R*,8R*)))-, Contopheron, 6-Cromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)- (+15 more)
INCI: TOCOPHERYL ACETATE
Tocopheryl Acetate (CAS 58-95-7) is a cosmetic antioxidant functioning as Antioxidant; stable ester form of vitamin E; skin-conditioning agent; requires. Reported NOAEL 83 mg/kg bw/day in rat (COSMOS_DB); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 58-95-7 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant; stable ester form of vitamin E; skin-conditioning agent; requires hydrolysis by skin esterases to release active alpha-tocopherol
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel final report: safe as used in cosmetics; present in thousands of formulations; FDA VCRP listed; no concentration restrictions.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tocopheryl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Tocopheryl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 83 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 125 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 833 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 4000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | =2000 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
Sensitization Profile
Contact sensitization data for Tocopheryl Acetate based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
botanical
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
Source: IVDK; ESSCA; NACDG
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 0.1–1 | 2 | CIR/VCRP |
| Sunscreen | 0.1–1 | 2 | CIR/VCRP |
| Body Lotion | 0.1–1 | 2 | CIR/VCRP |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "7695-91-2", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "2", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction…
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "botanical", "patch_test_frequency_pct": "0.3", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; ESSCA; NACDG"}
anti_aging
{"anti_aging_claim": "antioxidant-protection, hydration-plumping", "mechanism_of_action": "Cofactor for enzymatic reactions, antioxidant activity", "target_skin_layer": "epidermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "4-10", "clinical_study_duration_weeks": "12", "sample_size": "30", "double_blind": "Yes", "placebo_controlled": "Yes", "published_…
anti_pollution
{"cas_number": "7695-91-2", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "chain_breaking", "pollution_types_targeted": "PM2_5/UV_A", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": …
antioxidant
{"cas_number": "7695-91-2", "antioxidant_class": "vitamin", "chemical_subclass": "tocopherol ester", "molecular_weight_daltons": "472.74", "orac_value_umol_te_per_g": "400", "dpph_radical_scavenging_ic50_ug_per_ml": "80-120", "abts_trolox_equivalent": "0.3", "singlet_oxygen_quenching": "low", "superoxide_dismutase_mimetic": "low", "hydroxyl_radical_scavenging": "low", "lipid_peroxidation_inhibitio…
baby_pediatric
{"cas_number": "7695-91-2", "ingredient_class": "other", "pediatric_safety_rating": "excellent", "minimum_age_months": "0", "neonatal_safe": "yes", "premature_infant_safe": "yes", "skin_barrier_maturity_consideration": "Vitamin E ester, stable", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "Appropriate dosing im…
concentration
{"min_concentration_pct": "0.1", "max_concentration_pct": "3.0", "typical_concentration_pct": "0.5", "product_type": "Serum", "function_at_concentration": "Antioxidant", "source": "CIR Safety Assessment"}
deodorant
{"cas_number": "7695-91-2", "ingredient_class": "skin_conditioning_deo", "mechanism_of_action": "other", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "0", "odor_reduction_pct": "0", "bacteriostatic": "no", "bactericidal": "no", "microbiome_impact": "neutral", "axillary_microbiome_effect": "varies by ingredient", "MIC_value_if_antimicrobial": "varies", "astringenc…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Deodorizer
Flavouring and nutrient
Fragrance
Humectant
Preservative
Processing aids not otherwise specified
Softener and conditioner
Regulatory List Membership (4)
EU Regulated in Personal Care
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Tocopheryl Acetate.
Regulatory Flags
antioxidant
lipophilic
stable-ester
lower-bioactivity
requires-esterase
synergistic-with-vitamin-c
cir-reviewed
widely-used
epa_safer_alternative
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Tocopheryl Acetate by CAS number or substance name.
Studies
8
Lowest NOAEL
83 mg/kg bw/day
Highest NOAEL
4000 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
EC No.: 200-405-4
Alfacol
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (2R-(2*(4R*,8R*)))-
Contopheron
6-Cromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl acetate, (2R-(2*(4R*,8R*)))-
Ecofrol
EINECS 200-405-4
Ephynal acetate
Epsilan-M
E-Ferol
2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-cromanyl acetate, (+)-
Tocopherex
(+)-alpha-Tocopherol acetate
d-alpha-Tocopherol acetate
alpha-Tocopherol acetate, (2R,4'R,8'R)-
(+)-alpha-Tocopheryl acetate
(R,R,R)-alpha-Tocopheryl acetate
(2R,4'R,8'R)-alpha-Tocopheryl acetate
Tocophrin
Chemical Function
Preservative
Antioxidant
Softener and conditioner
Humectant
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Europe; Personal care
Europe; Personal care
Canada; pharmaceutical
Canada; pharmaceutical
Europe; supplements
Europe; food_additive; supplements
inert_ingredient; non_food_use; Pesticides
SCIL (9/2019)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1047
Adverse Event Associations
1660
Frequently Asked Questions
Is Tocopheryl Acetate allowed in the EU?
Tocopheryl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tocopheryl Acetate do in cosmetics?
Tocopheryl Acetate functions as: Antioxidant; stable ester form of vitamin E; skin-conditioning agent; requires hydrolysis by skin esterases to release active alpha-tocopherol. It is classified as a Antioxidant in our database. CAS number: 58-95-7.
What is the NOAEL for Tocopheryl Acetate?
The NOAEL (No Observed Adverse Effect Level) for Tocopheryl Acetate is 83 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.
Is Tocopheryl Acetate used outside cosmetics?
Tocopheryl Acetate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tocopheryl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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