What is the NOAEL for Ethyl tiglate?
Ethyl tiglate has 8 NOAEL studies in the database. The lowest reported value is 0MQ7E9082G UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ethyl tiglate
Also known as: BRN 1720895, Crotonic acid, 2-methyl-, ethyl ester, (E)-, EINECS 227-425-6, Ethyl (E)-2-methyl-2-butenoate, Ethyl trans-2-methyl-2-butenoate (+12 more)
CAS 5837-78-5
Ethyl tiglate (CAS 5837-78-5) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Ethyl tiglate
CAS Number
5837-78-5
DTXSID
DTXSID8047688
Molecular Formula
C7H12O2
InChI Key
OAPHLAAOJMTMLY-GQCTYLIASA-N
Monoisotopic Mass
128.08373
Synonyms
BRN 1720895Crotonic acid, 2-methyl-, ethyl ester, (E)-EINECS 227-425-6Ethyl (E)-2-methyl-2-butenoateEthyl trans-2-methyl-2-butenoateEthyl 2-methyl-2-butenoate, (E)-Ethyl alpha-methylcrotonateEthyl (E)-2-methylcrotonateEthyl trans-2-methylcrotonateEthyl 2-methylcrotonate, (E)-FEMA No. 2460(E)-2-Methyl-2-butenoic acid ethyl ester
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0MQ7E9082G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0MQ7E9082G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0MQ7E9082G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0MQ7E9082G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3375 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ethyl 2-methylcrotonate | 227-425-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL299599
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Ethyl tiglate?
Ethyl tiglate appears on 4 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Ethyl tiglate used in cosmetics?
Yes, Ethyl tiglate is also indexed as a cosmetic ingredient under the name Ethyl Tiglate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ethyl tiglate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Ethyl tiglate used outside industrial chemicals?
Ethyl tiglate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.