Is Ethyl Tiglate safe in cosmetics?
Ethyl Tiglate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Ethyl Tiglate
Also known as: BRN 1720895, Crotonic acid, 2-methyl-, ethyl ester, (E)-, EINECS 227-425-6, Ethyl (E)-2-methyl-2-butenoate, Ethyl trans-2-methyl-2-butenoate (+12 more)
INCI: ETHYL TIGLATE
Ethyl Tiglate (CAS 5837-78-5) is a cosmetic cosmetic ingredient functioning as Fragrance / Flavoring agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 5837-78-5 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance / Flavoring agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
ethyl 2-methylbut-2-enoate
InChIKey
OAPHLAAOJMTMLY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FDA EAFUS listed; FEMA GRAS (JECFA No. 1824)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Tiglate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 3375 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1824
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
(E)-ETHYL TIGLATE | 2008 | No safety concern at current levels of intake when used as a flavouring agent | ">RS 952-JECFA 69/78 | ">FAS 60-JECFA 69/291
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Ethyl Tiglate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
BRN 1720895
Crotonic acid, 2-methyl-, ethyl ester, (E)-
EINECS 227-425-6
Ethyl (E)-2-methyl-2-butenoate
Ethyl trans-2-methyl-2-butenoate
Ethyl 2-methyl-2-butenoate, (E)-
Ethyl alpha-methylcrotonate
Ethyl (E)-2-methylcrotonate
Ethyl trans-2-methylcrotonate
Ethyl 2-methylcrotonate, (E)-
FEMA No. 2460
(E)-2-Methyl-2-butenoic acid ethyl ester
NSC 55278
Tiglic acid, ethyl ester
UNII-0MQ7E9082G
2-Butenoic acid, 2-methyl-, ethyl ester, (2E)-
Ethyl 2-methylbut-2-enoate
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL299599
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
ETHYL TIGLATE
Food Category
flavoring
Frequently Asked Questions
Is Ethyl Tiglate allowed in the EU?
Ethyl Tiglate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Tiglate do in cosmetics?
Ethyl Tiglate functions as: Fragrance / Flavoring agent. It is classified as a cosmetic ingredient in our database. CAS number: 5837-78-5.
Is Ethyl Tiglate used outside cosmetics?
Ethyl Tiglate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ethyl Tiglate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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