What is the NOAEL for 4-O-alpha-D-Glucopyranosyl-D-glucitol?
4-O-alpha-D-Glucopyranosyl-D-glucitol has 24 NOAEL studies in the database. The lowest reported value is D65DG142WK UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-O-alpha-D-Glucopyranosyl-D-glucitol
Also known as: D-Glucitol, 4-O-alpha-D-glucopyranosyl-, Amalty, Lesys, Lycasin HBC, Mabit (+15 more)
CAS 585-88-6
4-O-alpha-D-Glucopyranosyl-D-glucitol (CAS 585-88-6) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
24
SOURCE
Chemical inventory jurisdictions
Regulatory lists
1
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
4-O-alpha-D-Glucopyranosyl-D-glucitol
CAS Number
585-88-6
DTXSID
DTXSID0044444
Molecular Formula
C12H24O11
InChI Key
VQHSOMBJVWLPSR-WUJBLJFYSA-N
Monoisotopic Mass
344.131862
Synonyms
D-Glucitol, 4-O-alpha-D-glucopyranosyl-AmaltyLesysLycasin HBCMabitMabit 50MMalti-MR 100MaltidexMaltidex CH 16385Maltidex M 16313Maltilite 5575Maltilite 7575
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
29 records
HumectantDeodorizerSoftener and conditionerFlavouring and nutrientPharmaceutical excipient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 24 of 24 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| D65DG142WK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D65DG142WK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D65DG142WK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D65DG142WK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2.5 | g/kg/day | NOAEL | gavage | New Zealand White rabbits (pregnant females) | CIR Safety Assessment |
| =2.5 | g/kg/day | NOAEL | gavage | New Zealand White rabbits (pregnant females) | CIR Safety Assessment |
| =2.5 | g/kg/day | NOAEL | gavage | New Zealand White rabbits (pregnant females) | CIR Safety Assessment |
| =2.5 | g/kg/day | NOAEL | gavage | New Zealand White rabbits (pregnant females) | CIR Safety Assessment |
| =4.5 | g/kg bw/day | NOAEL | oral (diet) | Crl:CD(SD)BR rats | CIR Safety Assessment |
| =4.5 | g/kg bw/day | NOAEL | oral (diet) | Crl:CD(SD)BR rats | CIR Safety Assessment |
| =4.5 | g/kg bw/day | NOAEL | oral (diet) | Crl:CD(SD)BR rats | CIR Safety Assessment |
| =4.5 | g/kg bw/day | NOAEL | oral (diet) | Crl:CD(SD)BR rats | CIR Safety Assessment |
| =18 | g/kg (rats); 43 g/kg (dogs) | NOAEL | oral (diet) | rats and dogs | CIR Safety Assessment |
| =18 | g/kg (rats); 43 g/kg (dogs) | NOAEL | oral (diet) | rats and dogs | CIR Safety Assessment |
| =18 | g/kg (rats); 43 g/kg (dogs) | NOAEL | oral (diet) | rats and dogs | CIR Safety Assessment |
| =18 | g/kg (rats); 43 g/kg (dogs) | NOAEL | oral (diet) | rats and dogs | CIR Safety Assessment |
| =69.09 | % | NOAEL | - | rat | CIR Safety Assessment |
| =69.09 | % | NOAEL | - | rat | CIR Safety Assessment |
| =69.09 | % | NOAEL | - | rat | CIR Safety Assessment |
| =69.09 | % | NOAEL | - | rat | CIR Safety Assessment |
| =7600 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
| =7600 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
| =15400 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
| =15400 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
Showing 24 of 24 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-O-α-D-glucopyranosyl-D-glucitol | 209-567-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
MALTITOL
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
E965(i) — ADI: NOT SPECIFIED mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include 4-O-alpha-D-Glucopyranosyl-D-glucitol?
4-O-alpha-D-Glucopyranosyl-D-glucitol appears on 1 regulatory/inventory list including Canada; consumer_product; Substances in Products - Canada (4/2014). Source: EPA CPDat.
Is 4-O-alpha-D-Glucopyranosyl-D-glucitol used in cosmetics?
Yes, 4-O-alpha-D-Glucopyranosyl-D-glucitol is also indexed as a cosmetic ingredient under the name Maltitol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-O-alpha-D-Glucopyranosyl-D-glucitol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is 4-O-alpha-D-Glucopyranosyl-D-glucitol used outside industrial chemicals?
4-O-alpha-D-Glucopyranosyl-D-glucitol also appears in cosmetics, pharmaceutical, food safety databases.