NOAEL Data Cosmetic Ingredient

N-(N-(N-(N-L-Tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine

Also known as: Enkephalin, leucine, Leu-enkephalin, L-Leucine, N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-, Leucine enkephalin

CAS 58822-25-6

N-(N-(N-(N-L-Tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine (CAS 58822-25-6) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB.

View cosmetic safety profile for sh-Pentapeptide-5 →

SOURCE noael studies public
NOAEL studies
4
SOURCE chemical inventory jurisdictions
Regulatory lists
0
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 10 fields
Name
N-(N-(N-(N-L-Tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine
CAS Number
58822-25-6
DTXSID
DTXSID00905127
Molecular Formula
C28H37N5O7
InChI Key
URLZCHNOLZSCCA-VABKMULXSA-N
Monoisotopic Mass
555.269299
Synonyms
Enkephalin, leucineLeu-enkephalinL-Leucine, N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-Leucine enkephalin

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 4 of 4 studies
ValueUnitEndpointRouteSpeciesSource
RI01R707R6UNIIFDA UNII substance identifier--openFDA substances
RI01R707R6UNIIFDA UNII substance identifier--openFDA substances
RI01R707R6UNIIFDA UNII substance identifier--openFDA substances
RI01R707R6UNIIFDA UNII substance identifier--openFDA substances

Showing 4 of 4 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ENKEPHALIN
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
6
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for N-(N-(N-(N-L-Tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine?

N-(N-(N-(N-L-Tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine has 4 NOAEL studies in the database. The lowest reported value is RI01R707R6 UNII. Source: openFDA substances.

Is N-(N-(N-(N-L-Tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine used in cosmetics?

Yes, N-(N-(N-(N-L-Tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine is also indexed as a cosmetic ingredient under the name sh-Pentapeptide-5. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for N-(N-(N-(N-L-Tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine come from?

Safety data is sourced from EPA ToxValDB, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is N-(N-(N-(N-L-Tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine used outside industrial chemicals?

N-(N-(N-(N-L-Tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine also appears in cosmetics, pharmaceutical databases.