Is sh-Pentapeptide-5 safe in cosmetics?
sh-Pentapeptide-5 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
sh-Pentapeptide-5
Also known as: Enkephalin, leucine, Leu-enkephalin, L-Leucine, N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-, Leucine enkephalin
INCI: SH-PENTAPEPTIDE-5
sh-Pentapeptide-5 (CAS 58822-25-6) is a cosmetic cosmetic ingredient functioning as Skin conditioning; Botox-like muscle relaxation (Leu-enkephalin mimic);. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 58822-25-6 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning; Botox-like muscle relaxation (Leu-enkephalin mimic); EGF-like skin regeneration
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
InChIKey
URLZCHNOLZSCCA-VABKMULXSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA UNII: RI01R707R6; no specific FDA monograph — general cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for sh-Pentapeptide-5.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for sh-Pentapeptide-5.
Known Synonyms
Enkephalin, leucine
Leu-enkephalin
L-Leucine, N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-
Leucine enkephalin
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ENKEPHALIN
ChEMBL ID
CHEMBL8234
Frequently Asked Questions
Is sh-Pentapeptide-5 allowed in the EU?
sh-Pentapeptide-5 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does sh-Pentapeptide-5 do in cosmetics?
sh-Pentapeptide-5 functions as: Skin conditioning; Botox-like muscle relaxation (Leu-enkephalin mimic); EGF-like skin regeneration. It is classified as a cosmetic ingredient in our database. CAS number: 58822-25-6.
Is sh-Pentapeptide-5 used outside cosmetics?
sh-Pentapeptide-5 also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check sh-Pentapeptide-5 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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