NOAEL Data REACH Registered Cosmetic Ingredient

Alpha-Vitamin E

Also known as: 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)-, D-alpha-Tocopherol, E Prolin, (all-R)-alpha-Tocopherol, Antisterility vitamin (+15 more)

CAS 59-02-9

Alpha-Vitamin E (CAS 59-02-9) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.

View cosmetic safety profile for Tocopherol →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Alpha-Vitamin E

CAS Number

59-02-9

DTXSID

DTXSID0026339

Molecular Formula

C29H50O2

InChI Key

GVJHHUAWPYXKBD-IEOSBIPESA-N

Monoisotopic Mass

430.381081

Synonyms

2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)-D-alpha-TocopherolE Prolin(all-R)-alpha-TocopherolAntisterility vitamin2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, (2R-(2R*(4R*,8R*)))-Covi-OxEINECS 200-412-22,5,7,8-Tetramethyl-2-(4',8',12'-trimethyltridecyl)-6-chromanolalpha-Tocopherol acidalpha-TokoferolViprimol

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 13 records

Softener and conditionerFragranceAntioxidantPharmaceuticalPreservativeBinder

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
IFRA Transparency	IFRA	IFRA
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
Europe; supplements	EU	CPCat
Europe; food_additive; supplements	EU	CPCat
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 25 of 25 studies

Value	Unit	Endpoint	Route	Species	Source
>=0.15	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
<=2	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
>200	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
>1000	ug/mL	CV75	Dermal	-	NTP_ICE_skin_sensitization
114.6	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
>2000	uM	EC3	Dermal	-	NTP_ICE_skin_sensitization
N9PR3490H9	UNII	FDA UNII substance identifier	-	-	openFDA substances
N9PR3490H9	UNII	FDA UNII substance identifier	-	-	openFDA substances
N9PR3490H9	UNII	FDA UNII substance identifier	-	-	openFDA substances
N9PR3490H9	UNII	FDA UNII substance identifier	-	-	openFDA substances
2.09	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
=21	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=125	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=500	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=180	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=540	mg/day	NOAEL	oral	Human	ToxValDB_EFSA
=540	mg/day	NOAEL	-	Human	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=1028	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1086	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1600	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=2000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=50	mg/kg bw/day	NOEL	injection	Rat	ToxValDB_ECOTOX
=100	mg/kg bw/day	NOEL	injection	Rat	ToxValDB_ECOTOX
=550	mg/kg bw/day	NOEL	oral	Mouse	ToxValDB_ECHA_IUCLID
>1028	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 25 of 25 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	α-tocopherol	200-412-2	ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ALPHA-TOCOPHEROL

ChEMBL Phase

Not listed

Adverse Events

467

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E307 — ADI: 0.15 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Alpha-Vitamin E?

Alpha-Vitamin E has 25 NOAEL studies in the database. The lowest reported value is 0.15 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.

What regulatory lists include Alpha-Vitamin E?

Alpha-Vitamin E appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, IFRA Transparency, SCIL (9/2019), and 3 more. Source: EPA CPDat.

Is Alpha-Vitamin E used in cosmetics?

Yes, Alpha-Vitamin E is also indexed as a cosmetic ingredient under the name Tocopherol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Alpha-Vitamin E come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Alpha-Vitamin E used outside industrial chemicals?

Alpha-Vitamin E also appears in cosmetics, pharmaceutical, food safety, cannabis databases.