What is the NOAEL for Alpha-Vitamin E?
Alpha-Vitamin E has 22 NOAEL studies in the database. The lowest reported value is 0.15 mg/kg via oral in Human. Source: WHO/JECFA.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Alpha-Vitamin E
Also known as: 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)-, D-alpha-Tocopherol, E Prolin, (all-R)-alpha-Tocopherol, Antisterility vitamin (+15 more)
CAS 59-02-9
Alpha-Vitamin E (CAS 59-02-9) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
22
SOURCE
Chemical inventory jurisdictions
Regulatory lists
6
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Alpha-Vitamin E
CAS Number
59-02-9
Molecular Formula
C29H50O2
InChI Key
GVJHHUAWPYXKBD-IEOSBIPESA-N
Monoisotopic Mass
430.381081
Synonyms
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)-D-alpha-TocopherolE Prolin(all-R)-alpha-TocopherolAntisterility vitamin2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, (2R-(2R*(4R*,8R*)))-Covi-OxEINECS 200-412-22,5,7,8-Tetramethyl-2-(4',8',12'-trimethyltridecyl)-6-chromanolalpha-Tocopherol acidalpha-TokoferolViprimol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
13 records
Softener and conditionerFragranceAntioxidantPharmaceuticalPreservativeBinder
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 22 of 22 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| >=0.15 | mg/kg | ADI | oral | Human | WHO/JECFA |
| <=2 | mg/kg | ADI | oral | Human | WHO/JECFA |
| >200 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| >1000 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 114.6 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| >2000 | uM | EC3 | Dermal | - | NTP ICE skin sensitization |
| N9PR3490H9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2.09 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| =21 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| =125 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| =500 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| =180 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =540 | mg/day | NOAEL | oral | Human | EFSA |
| =540 | mg/day | NOAEL | - | Human | EFSA |
| =1028 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =1086 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =1600 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =2000 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =50 | mg/kg bw/day | NOEL | injection | Rat | ToxValDB ECOTOX |
| =100 | mg/kg bw/day | NOEL | injection | Rat | ToxValDB ECOTOX |
| =550 | mg/kg bw/day | NOEL | oral | Mouse | ECHA |
| >1028 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
Showing 22 of 22 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | α-tocopherol | 200-412-2 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
ALPHA-TOCOPHEROL
ChEMBL Phase
Not listed
Adverse Events
467
Bioactivity
9
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
E307 — ADI: 0.15 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Alpha-Vitamin E?
Alpha-Vitamin E appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, IFRA Transparency, SCIL (9/2019), and 3 more. Source: EPA CPDat.
Is Alpha-Vitamin E used in cosmetics?
Yes, Alpha-Vitamin E is also indexed as a cosmetic ingredient under the name Tocopherol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Alpha-Vitamin E come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Alpha-Vitamin E used outside industrial chemicals?
Alpha-Vitamin E also appears in cosmetics, pharmaceutical, food safety, cannabis databases.