NOAEL Data REACH Registered Cosmetic Ingredient

Nicotinic acid

Also known as: Niacin, Vitamin B3 (niacin or nicotinic acid), 5-22-02-00057, Acidum nicotinicum, BRN 0109591 (+15 more)

CAS 59-67-6

Nicotinic acid (CAS 59-67-6) is a chemical substance. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.

View cosmetic safety profile for NIACIN →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Nicotinic acid

CAS Number

59-67-6

DTXSID

DTXSID1020932

Molecular Formula

C6H5NO2

InChI Key

PVNIIMVLHYAWGP-UHFFFAOYSA-N

Monoisotopic Mass

123.032028

Synonyms

NiacinVitamin B3 (niacin or nicotinic acid)5-22-02-00057Acidum nicotinicumBRN 0109591Caswell No. 598Davitamon PPDirektanEINECS 200-441-0EPA Pesticide Chemical Code 056701NicaginNicocidin

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	WARNING
GHS Hazard Statements	Causes eye irritation Harmful to aquatic life
Short-term Effects	The substance is mildly irritating to the eyes.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 11 records

Anti-static agentHumectantSoftener and conditionerFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 10 records

List	Keyword	Source
Europe; supplements	EU	CPCat
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
Canada; pharmaceutical	DrugBank	DrugBank
Canada; pharmaceutical	DrugBank	DrugBank
Canada; pharmaceutical	DrugBank	DrugBank
pharmaceutical	US International Trade Commission	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
pharmaceutical	US International Trade Commission	CPCat
Europe; supplements	EU	CPCat
Europe; food_additive; supplements	EU	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 23 of 23 studies

Value	Unit	Endpoint	Route	Species	Source
3.54	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
=0.5	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
2679MF687A	UNII	FDA UNII substance identifier	-	-	openFDA substances
2679MF687A	UNII	FDA UNII substance identifier	-	-	openFDA substances
2679MF687A	UNII	FDA UNII substance identifier	-	-	openFDA substances
2679MF687A	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.594	fraction	Fu	-	Human	NTP_ICE_adme_parameters
=4500	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=5210	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=7000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=8900	mg/kg bw	LD50	oral	Rat (Female)	NTP_ICE_acute_oral
=11650	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
-	unitless	Model Score	-	-	NTP_ICE_endocrine
49	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=50	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
100	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
150	mg/kg bw/day	NOAEL	oral	rabbit	COSMOS_DB
300	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
395	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
400	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
500	mg/kg bw/day	NOAEL	oral	dog	COSMOS_DB
1000	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
2000	mg/kg bw/day	NOAEL	oral	dog	COSMOS_DB

Showing 23 of 23 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Nicotinic acid	200-441-0	ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL NIACIN

ChEMBL Phase

Adverse Events

1170

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Nicotinic acid?

Nicotinic acid has 23 NOAEL studies in the database. The lowest reported value is 0.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Nicotinic acid?

Nicotinic acid appears on 6 regulatory/inventory lists including Europe; supplements, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Canada; pharmaceutical, and 3 more. Source: EPA CPDat.

Is Nicotinic acid used in cosmetics?

Yes, Nicotinic acid is also indexed as a cosmetic ingredient under the name NIACIN. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Nicotinic acid come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Nicotinic acid used outside industrial chemicals?

Nicotinic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.