What is the NOAEL for Nicotinic acid?
Nicotinic acid has 20 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Nicotinic acid
Also known as: Niacin, Vitamin B3 (niacin or nicotinic acid), 5-22-02-00057, Acidum nicotinicum, BRN 0109591 (+15 more)
CAS 59-67-6
Nicotinic acid (CAS 59-67-6) is a chemical substance. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.
SOURCE
NOAEL studies
NOAEL studies
20
SOURCE
Chemical inventory jurisdictions
Regulatory lists
10
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Nicotinic acid
CAS Number
59-67-6
Molecular Formula
C6H5NO2
InChI Key
PVNIIMVLHYAWGP-UHFFFAOYSA-N
Monoisotopic Mass
123.032028
Synonyms
NiacinVitamin B3 (niacin or nicotinic acid)5-22-02-00057Acidum nicotinicumBRN 0109591Caswell No. 598Davitamon PPDirektanEINECS 200-441-0EPA Pesticide Chemical Code 056701NicaginNicocidin
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Causes eye irritation Harmful to aquatic life |
| Short-term Effects | The substance is mildly irritating to the eyes. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
11 records
Anti-static agentHumectantSoftener and conditionerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
10 records
| List | Keyword | Source |
|---|---|---|
| Europe; supplements | EU | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| pharmaceutical | US International Trade Commission | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 20 of 20 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 3.54 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| =0.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 2679MF687A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.594 | fraction | Fu | - | Human | NTP ICE adme parameters |
| =4500 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =5210 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =7000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =8900 | mg/kg bw | LD50 | oral | Rat (Female) | NTP ICE acute oral |
| =1.165e+4 | mg/kg bw | LD50 | oral | Rat (Male) | NTP ICE acute oral |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 49 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 100 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 150 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS DB |
| 300 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 395 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 400 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 500 | mg/kg bw/day | NOAEL | oral | dog | COSMOS DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 2000 | mg/kg bw/day | NOAEL | oral | dog | COSMOS DB |
Showing 20 of 20 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Nicotinic acid | 200-441-0 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
NIACIN
ChEMBL Phase
4
Adverse Events
1170
Bioactivity
16
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Nicotinic acid?
Nicotinic acid appears on 6 regulatory/inventory lists including Europe; supplements, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Canada; pharmaceutical, and 3 more. Source: EPA CPDat.
Is Nicotinic acid used in cosmetics?
Yes, Nicotinic acid is also indexed as a cosmetic ingredient under the name NIACIN. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Nicotinic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Nicotinic acid used outside industrial chemicals?
Nicotinic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.