NIACIN
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Toxicological Studies
10 study endpoints found for NIACIN. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 150 mg/kg bw/day | oral | rabbit | Subchronic | COSMOS_DB |
| NOAEL | 150 mg/kg bw/day | oral | rabbit | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | dog | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | dog | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | dog | Short Term Toxicity | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
NIACIN is listed in the EU CosIng database with functions: Antistatic, Smoothing It is permitted in the EU without specific restrictions.
Regulatory Flags
Frequently Asked Questions
Is NIACIN safe in cosmetics?
NIACIN is listed in the EU CosIng database with functions: Antistatic, Smoothing It is permitted in the EU without specific restrictions. The EU classifies NIACIN as "Permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is NIACIN allowed in the EU?
NIACIN EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NIACIN do in cosmetics?
NIACIN functions as: Antistatic, Smoothing. It is classified as a cosmetic ingredient in our database. CAS number: 59-67-6.
What is the NOAEL for NIACIN?
The NOAEL (No Observed Adverse Effect Level) for NIACIN is 1000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is NIACIN classified as hazardous under GHS?
NIACIN carries a GHS signal word of "WARNING". Hazard statements: Causes eye irritation Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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