What is the NOAEL for Butyl propionate?
Butyl propionate has 30 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Butyl propionate
Also known as: Propanoic acid, butyl ester, 4-02-00-00708, BRN 1700932, Butyl propanoate, n-Butyl propanoate (+10 more)
CAS 590-01-2
Butyl propionate (CAS 590-01-2) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
NOAEL studies
NOAEL studies
30
SOURCE
Chemical inventory jurisdictions
Regulatory lists
12
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
Butyl propionate
CAS Number
590-01-2
Molecular Formula
C7H14O2
InChI Key
BTMVHUNTONAYDX-UHFFFAOYSA-N
Monoisotopic Mass
130.09938
Synonyms
Propanoic acid, butyl ester4-02-00-00708BRN 1700932Butyl propanoaten-Butyl propanoateEINECS 209-669-5FEMA No. 2211NSC 8449UNII-2NXC4AK99EButyl ester of propanoic acidButyl propionate [UN1914] [Flammable liquid]FEMA 2211
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The vapour is irritating to the respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
FragranceFlavouring and nutrientSolvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
12 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; emissions; Europe; nondetect; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 30 of 30 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =64 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| 33.8 | min | ET50 | Dermal | - | NTP ICE skin irritation |
| 2NXC4AK99E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1350 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| >23.78 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =3993 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB HPVIS |
| =4260 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB HPVIS |
| =1.331e+4 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB HPVIS |
| =1331 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB HPVIS |
| =2662 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB HPVIS |
| =7987 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB HPVIS |
| >=1.065e+4 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB HPVIS |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| 31.52 | % | Viability | Dermal | - | NTP ICE skin irritation |
| 95.6 | % | Viability | Dermal | - | NTP ICE skin irritation |
| 97.9 | % | Viability | Dermal | - | NTP ICE skin irritation |
| 107.7 | % | Viability | Dermal | - | NTP ICE skin irritation |
| 132.5 | % | Viability | Dermal | - | NTP ICE skin irritation |
| 83.7 | % | Viability (18 hours) | Dermal | - | NTP ICE skin irritation |
| 47.9 | % | Viability (240 minutes) | Dermal | - | NTP ICE skin irritation |
| 58.7 | % | Viability (240 minutes) | Dermal | - | NTP ICE skin irritation |
| 63.1 | % | Viability (240 minutes) | Dermal | - | NTP ICE skin irritation |
| 95.3 | % | Viability (3 minutes) | Dermal | - | NTP ICE skin irritation |
| 106.3 | % | Viability (3 minutes) | Dermal | - | NTP ICE skin irritation |
| 111.5 | % | Viability (3 minutes) | Dermal | - | NTP ICE skin irritation |
| 83.6 | % | Viability (42 hours) | Dermal | - | NTP ICE skin irritation |
| 70.4 | % | Viability (60 minutes) | Dermal | - | NTP ICE skin irritation |
| 80.5 | % | Viability (60 minutes) | Dermal | - | NTP ICE skin irritation |
| 105.7 | % | Viability (60 minutes) | Dermal | - | NTP ICE skin irritation |
Showing 30 of 30 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Butyl propionate | 209-669-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL3561586
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Butyl propionate?
Butyl propionate appears on 7 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 4 more. Source: EPA CPDat.
Is Butyl propionate used in cosmetics?
Yes, Butyl propionate is also indexed as a cosmetic ingredient under the name Butyl Propionate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Butyl propionate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Butyl propionate used outside industrial chemicals?
Butyl propionate also appears in cosmetics, pharmaceutical databases.